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Non-dopamine containing efferents of substantia nigra: The pathway to the lower brain stem

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Summary

In animals pretreated with 6-hydroxydopamine, the descending efferent connections of the substantia nigra are restricted to a bilateral projection to the superior colliculus and a pathway which stops in the dorso-lateral reticular formation of the pons.

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References

  • Beckstead, R. M., Domesick, V. B., Nauta, W. J. H. Efferent connections of the substantia nigra and ventral tegmental area in the rat. Brain Res.175, 191–217 (1979).

    Google Scholar 

  • Bentivoglio, M., van der Kooy, D., Kuypers, H. G. J. M. The organization of the efferent projections of the substantia nigra in the rat. A retrograde fluorescent double labelling study. Brain Res.174, 1–17 (1979).

    Google Scholar 

  • Cole, M., Nauta, W. J. H., Mehler, W. H. The ascending efferent projections of the substantia nigra. Trans. Amer. Neurol. Assoc.89, 74–78 (1964).

    Google Scholar 

  • Crow, T. J., Arbuthnott, G. W. Function of catecholamine-containing neurones in mammalian central nervous system. Nature New Biol.238, 245–246 (1972).

    Google Scholar 

  • Donaldson, I. A., Dolphin, A., Jenner, P., Marsden, C. D., Pycock, C. The involvement of noradrenaline in motor activity as shown by rotational behaviour after unilateral lesions of the locus coeruleus. Brain99, 427–446 (1976).

    Google Scholar 

  • Drury, R. A. B., Wallington, E. A., Cameron, R. Carleton's histological technique, p. 133. London: Oxford University Press. 1967.

    Google Scholar 

  • Faull, R. L. M., Mehler, W. H. The cells of origin of nigrotectal, nigrothalamic and nigrostriatal projections in the rat. Neuroscience3, 989 to 1002 (1978).

    Google Scholar 

  • Graybiel, A. M. Organization of the nigrotectal connection: an experimental tracer study in the cat. Brain Res.143, 339–348 (1978).

    Google Scholar 

  • Guyenet, P. G., Aghajanian, G. K. Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra. Brain Res.150, 69–84 (1978).

    Google Scholar 

  • Hedreen, J. Separate demonstration of dopaminergic and non-dopaminergic projections of substantia nigra in the rat. Anat. Rec.169, 338 (1971).

    Google Scholar 

  • Hedreen, J. Brainstem projections of rat substantia nigra. Anat. Rec. 190,2, 417 (1978).

    Google Scholar 

  • Hökfelt, T., Ungerstedt, U. Specificity of 6-OH-DA induced degeneration of central monoamine neurones. An electron and fluorescence microscopic study with special reference to intracerebral injection in the nigrostriatal dopamine system. Brain Res.60, 267–297 (1973).

    Google Scholar 

  • Hopkins, D. A., Niessen, L. W. Substantia nigra projections to the reticular formation, superior colliculus and central gray in the rat, cat and monkey. Neuroscience Letters2, 253–259 (1976).

    Google Scholar 

  • Jenner, P., Leigh, N., Marsden, C. D., Reavill, C.: Dopamine mediated circling behaviour is modulated by lesions of the ventromedial nucleus of the thalamus. Brit. J. Pharmac.67, 432P (1979).

  • Kluver, H., Barrera, E. A method for the combined staining of cells and fibres in the nervous system. J. Neuropath. exp. Neurol.12, 400–403 (1953).

    Google Scholar 

  • Sakai, K., Touret, M., Salvert, D., Leger, L., Jouvet, M. Afferent projections to locus coeruleus as visualized by the horseradish peroxidase technique. Brain Res.119, 21–24 (1977).

    Google Scholar 

  • Simon, H., Le Moal, M., Stinus, L., Calas, A. Anatomical relationships between the ventral mesencephalic tegmentum—A10 region and the locus coeruleus as demonstrated by anterograde and retrograde tracing techniques. J. Neural Transm.44, 77–86 (1979).

    Google Scholar 

  • Tulloch, I. F., Arbuthnott, G. W., Wright, A. K. Topographical organization of the striatonigral pathway revealed by anterograde and retrograde neuroanatomical tracing techniques. J. Anat.127, 425–441 (1978).

    Google Scholar 

  • Ungerstedt, U. 6-Hydroxydopamine induced degeneration of central monoamine neurones. Eur. J. Pharmac.5, 107–110 (1968).

    Google Scholar 

  • Ungerstedt, U., Arbuthnott, G. W. Quantitative recording of rotational behaviour in rats after 6-OH-DA lesions of the nigrostriatal DA system. Brain Res.24, 485–493 (1970).

    Google Scholar 

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Author notes

  1. A. K. Wright

    Present address: MRC Brain Metabolism Unit, University Department of Pharmacology, Edinburgh, UK

Authors and Affiliations

  1. MRC Brain Metabolism Unit, University Department of Pharmacology, Edinburgh, UK

    G. W. Arbuthnott

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  1. A. K. Wright
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  2. G. W. Arbuthnott
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Wright, A.K., Arbuthnott, G.W. Non-dopamine containing efferents of substantia nigra: The pathway to the lower brain stem. J. Neural Transmission 47, 221–226 (1980). https://doi.org/10.1007/BF01250602

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  • DOI: https://doi.org/10.1007/BF01250602

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