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Presence of neutralizing antibody to canine distemper virus in sera of patients with subacute sclerosing panencephalitis

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Summary

Sera collected from three patients with subacute sclerosing panencephalitis (SSPE) at various stages of the disease were demonstrated to contain remarkably high levels of neutralizing antibody to canine distemper virus in proportion to the well known high antibody titers against measles virus. In contrast, neutralizing antibody to canine distemper virus was detected only at low titer in sera of convalescents from natural measles, or of measles with or without atypical measles symptom following vaccination, as well as in sera of children vaccinated with live or killed measles vaccine. Anti-measles sera prepared in various experimental animals also contained neutralizing antibody to canine distemper virus only at low titer.

The significance of these findings is discussed in relevance to the possible involvement of canine distemper virus in the pathogenesis of SSPE.

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Author notes

  1. T. A. Sato

    Present address: Department of Measles Virus, National Institute of Health, Musashi-Murayama, Tokyo, Japan

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  1. Department of Measles Virus, National Institute of Health, Musashi-Murayama, Tokyo, Japan

    K. Yamanouchi & A. Shishido

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  1. T. A. Sato
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Sato, T.A., Yamanouchi, K. & Shishido, A. Presence of neutralizing antibody to canine distemper virus in sera of patients with subacute sclerosing panencephalitis. Archiv f Virusforschung 42, 36–41 (1973). https://doi.org/10.1007/BF01250505

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  • DOI: https://doi.org/10.1007/BF01250505

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