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Clozapine induced increase of human plasma norepinephrine

Journal of Neural Transmission volume 46, pages 175–180 (1979)Cite this article

Summary

Four psychotic patients and 5 controls were treated with clozapine (200–400 mg/day during 30 days, patients, respectively 100 mg/day during 7 days, controls) and plasma norepinephrine (NE) concentration was measured. In the morning, shortly after end of sleep, plasma NE concentration was significantly increased under clozapine treatment in both populations. The effects of clozapine were explained with a direct pharmacological action of the drug on NE receptors.

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Author notes

  1. E. Rüther

    Present address: Psychiatrische Klinik, Universität München, Federal Republic of Germany

Affiliations

  1. Psychiatrische Klinik, Universität München, Federal Republic of Germany

    M. Sarafoff & L. Davis

Authors
  1. M. Sarafoff
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  2. L. Davis
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  3. E. Rüther
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Sarafoff, M., Davis, L. & Rüther, E. Clozapine induced increase of human plasma norepinephrine. J. Neural Transmission 46, 175–180 (1979). https://doi.org/10.1007/BF01250337

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  • DOI: https://doi.org/10.1007/BF01250337

Key words

  • Clozapine
  • norepinephrine