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Markers for measles virus

I. Physical Properties

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Summary

Six measles virus strains possessing different pathogenic properties for man and/or small laboratory animals were examined for stability to heating at 45°C, inactivation after irradiation with ultra-violet (UV) light, susceptibility to freezing and thawing, and inhibition of infectivity by absorption with brain tissue. The viruses included the Edmonston cell culture-adapted strain, the Edmonston B and Schwarz attenuated vaccine strains, a neurotropic hamster brain-adapted strain, and 2 strains isolated from the brains of 2 cases of subacute sclerosing panencepahlitis (SSPE).

Neurotropism of a strain was characteristically associated with increased sensitivity to heating and resistance to freeze-thaw damage. The highly neurotropic hamster brain-adapted strain was significantly more stable to UV irradiation and its infectivity was sharply reduced by adsorption with brain extracts.

The persistence of the physical markers was largely dependent on the degree of cell culture adaptation.

The Schwarz attenuated strain possessed markers which distinguished it both from strain Edmonston B and the other measles virus strains.

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Author notes

  1. Paul Albrecht

    Present address: U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Division of Biologics Standards, Laboratory of Virology and Rickettsiology, Bethseda, Maryland, USA

  2. Heinz P. Schumacher

    Present address: Universitäts-Kinderklinik, D-78, Freiburg/Br., Germany

Authors and Affiliations

  1. U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Division of Biologics Standards, Laboratory of Virology and Rickettsiology, Bethseda, Maryland, USA

    Heinz P. Schumacher

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  1. Paul Albrecht
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  2. Heinz P. Schumacher
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Recipient of a Public Health Service International Postdoctoral Research Fellowship No. 1 FO 5 TWO 1369-01.

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Albrecht, P., Schumacher, H.P. Markers for measles virus. Archiv f Virusforschung 36, 23–35 (1972). https://doi.org/10.1007/BF01250292

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  • DOI: https://doi.org/10.1007/BF01250292

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