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The isolation of S.S.P.E. measles virus in newborn mice

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Summary

The isolation of measles virus in newborn mice and Vero cell cultures from biopsy specimens obtained from two cases of S.S.P.E. is reported. Under the described experimental conditions the newborn mice proved to be as sensitive as Vero cells to one of the isolated viruses. Evidence for the presence of cell-free virus was obtained from first and second mouse brain passes of the isolates. It is considered that mouse inoculation may prove of greater value than co-cultivation for the initial isolation of virus from biopsied brain tissues from some cases of S.S.P.E.

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Author notes

  1. L. W. Greenham

    Present address: Department of Bacteriology, Bristol University, Bristol

Authors and Affiliations

  1. Department of Bacteriology, Bristol University, Bristol

    D. B. Peacock, T. J. Hill, Betty Brownell & W. H. Schutt

  2. The Burden Neuropathologieal Laboratory, Frenchay Hospital, Bristol

    L. W. Greenham, D. B. Peacock, T. J. Hill, Betty Brownell & W. H. Schutt

  3. Bristol Royal Hospital for Sick Children, St. Michael's Hill, Bristol, Great Britain

    L. W. Greenham, D. B. Peacock, T. J. Hill, Betty Brownell & W. H. Schutt

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  1. L. W. Greenham
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  2. D. B. Peacock
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  3. T. J. Hill
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  4. Betty Brownell
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  5. W. H. Schutt
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Greenham, L.W., Peacock, D.B., Hill, T.J. et al. The isolation of S.S.P.E. measles virus in newborn mice. Archiv f Virusforschung 44, 109–120 (1974). https://doi.org/10.1007/BF01250219

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  • DOI: https://doi.org/10.1007/BF01250219

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