Summary
The properties of two influenza A viruses attenuated for man were studied and compared with those of their parent strains. Attenuation had previously been effected by selection of viruses wholly or partially resistant to horse serum inhibitor. Experiments with low-temperature passage were preliminary. Inhibitorresistant viruses eluted faster from red blood cells than inhibitor-sensitive viruses, but there was no relationship between neuraminidase activity and rate of elution. Other conventional markers were similar in wild and attenuated strains. Mention was made of the need to attenuate viruses by other methods and to study their properties in the laboratory.
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In receipt of a World Health Organization junior research training grant.
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Willers, H., Beare, A.S. Laboratory characteristics of influenza a viruses attenuated for man. Archiv f Virusforschung 30, 187–194 (1970). https://doi.org/10.1007/BF01250188
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DOI: https://doi.org/10.1007/BF01250188