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Systemic induction of interferon in chicks with various NDV strains

II. Nature of the interferon inducing agent

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Summary

The interferon (IF) inducing ability of avirulent and virulent NDV strains stimulating in chicks early and late IFs, respectively, was differently affected on inactivation of the virus by various methods. With the avirulent strains, the IF inducing ability and infectivity are unrelated, whereas with the virulent strains they are closely related. Damage of the viral nucleic acid (UV-irradiation, inactivation with β-propiolactone) affected the IF inducing ability namely of the virulent strains, whereas damage to viral protein (trypsin treatment, neutralization by immune serum) namely that of the avirulent strains.

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References

  1. Borecky, L., andV. Lackovic: Induction of interferon-like substances by nonviral agents: In: The Interferons (G. Rita ed.), p. 9. New York and London: Academic Press, 1968.

    Google Scholar 

  2. Burke, D. C., andA. Isaacs: Further studies on interferon. Brit. J. exp. Path.39, 78 (1958).

    Google Scholar 

  3. Field, A. K., A. A. Tytell, G. P. Lampson, andM. R. Hilleman: Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes. Proc. nat. Acad. Sci. (Wash.)58, 1004 (1967).

    Google Scholar 

  4. LeGrippo, G. A., andF. W. Hartman: Antigenicity of β-propiolactone inactivated virus vaccines. J. Immunol.75, 123 (1955).

    Google Scholar 

  5. Ho, M.: Identification and “induction” of interferon. Bact. Rev.28, 367 (1964).

    Google Scholar 

  6. Ho, M.: The production of interferons. In: Interferons (N. B. Finter ed.), p. 21. Amsterdam: North Holland Publishing Co., 1966.

    Google Scholar 

  7. Lomniczi. B.: Viral pathogenicity and interferon production. Acta vet. Acad. Sci. hung.18, 133 (1968).

    Google Scholar 

  8. Lomniczi, B., G. Pethes, andF. Kemenes: Effect of X-irradiation and bursectomy on interferons induced in chickens by Newcastle disease virus. Z. Immun.- Forsch.137, 314 (1969).

    Google Scholar 

  9. Pusztai, R., I. Béládi, M. Bakay, andI. Mucsi: Effect of ultraviolet irradiation and heating on the interferon-inducing capacity of human adenoviruses. J. gen. Virol.4, 169 (1969).

    Google Scholar 

  10. Skehel, J. J., andD. C. Burke: Interferon production by Semliki Forest virus inactivated with hydroxylamine. J. gen. Virol.3, 35 (1968).

    Google Scholar 

  11. Tytell, A. A., G. P. Lampson, A. K. Field, andM. R. Hilleman: Inducers of interferon and host resistance. III. Double-stranded RNA from reovirus type 3 virions (REO 3-RNA). Proc. nat. Acad. Sci. (Wash.)58, 1710 (1967).

    Google Scholar 

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  1. B. Lomniczi

    Present address: Veterinary Medical Research Institute of the Hungarian Academy of Sciences, Budapest, Hungary

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    1. B. Lomniczi
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    Lomniczi, B. Systemic induction of interferon in chicks with various NDV strains. Archiv f Virusforschung 30, 167–172 (1970). https://doi.org/10.1007/BF01250185

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    • DOI: https://doi.org/10.1007/BF01250185

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