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Action du bromhydrate d'éthidium sur le développement du virus vaccinal dans des cellules en culture de rein de babouin

Action of ethidium bromide on the development of vaccinia virus in baboon kidney cell cultures. II

II. Action sur les synthèses d'ADN et d'ARN de cellules infectées et non infectées

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Résumé

L'action du bromhydrate d'éthidium (BET) sur le développement du virus de la vaccine peut être attribuée à la complexation des génomes cellulaire et viral par ce produit bloquant leur duplication et ralentissant leurs transcriptions. Les travaux deWaring (10) suggèrent que cette action inhibitrice pourrait être due à l'inhibition par le BET des ADN-polymérases et ARN-polymérases dépendant de l'ADN.

Summary

The action of ethidium bromide (EB) on the development of vaccinia virus may be attributed to the combination of EB with cellular and viral DNA blocking their duplications and decreasing their transcriptions. The results obtained byWaring (10) suggest that this inhibitory action may be attributed to the inhibitory action of EB on DNA-polymerase and RNA-DNA-dependent-polymerase.

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Bibliographie

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Author notes

  1. J. M. Raya

    Present address: Instituto de Microbiologia, Universidad Nacional de Tucuman, Ayacucho 482, Tucuman, Argentina

  2. R. Vilaginès

    Present address: Dr. McAuslan's Laboratory, Roche Institute of Molecular Biology, 07110, Nutley, NJ, USA

Authors and Affiliations

  1. Service des Virus Institut Pasteur, Paris, France

    J. M. Raya & R. Vilaginès

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  1. J. M. Raya
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  2. R. Vilaginès
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Raya, J.M., Vilaginès, R. Action du bromhydrate d'éthidium sur le développement du virus vaccinal dans des cellules en culture de rein de babouin. Archiv f Virusforschung 30, 155–158 (1970). https://doi.org/10.1007/BF01250183

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  • DOI: https://doi.org/10.1007/BF01250183

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