Summary
Previous evidence has shown that histamine (HA) increases prolactin (PRL) release in adult male and female rats. This response is depending on the age of the animals and some differences were appreciated between male and female rats. In addition, at 20 days of age the PRL response was greater than earlier ages. The purpose of the present communication was to study further this response and to define the type of HA receptor that may be involved in the mediation of this PRL response.
Animals of both sexes, at 5 or 20 days of age, were injected into the lateral brain ventricles with three log-doses of histamine (HA), 2,2, pyridil-ethylamine (2 PEA, and H1-histamine agonist), 4 methyl-histamine (4 MHA, an H2-histamine agonist) or saline as control. Fifteen minutes later a sample of blood was taken from the jugular vein and plasma PRL levels were determined by RIA. In complete agreement with previous work, results obtained indicate that HA is able to induce an increased PRL release in 20-day-old animals. This response was not identical in rats of both sexes. Female rats appeared to be more sensitive to HA than male rats. 2 PEA, was not able to reproduce the response in male rats but it was effective in female animals. 4 MHA induced the response in both sexes in a similar way than HA.
At 5 days of age in male rats HA had no effect on PRL release. In female rats, instead, only the greater dose was able to induce a small but statistically significant response.
In general, nor 2 PEA or 4 MHA were able to stimulate the PRL release at this age. The present results suggest that H2-histamine receptors are present in male rats and in female animals both types of receptors may be involved in the control of PRL release.
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References
Adam, H. M., Hye, K. A.: Concentration of histamine in different parts of the brain and hypophysis of cat and its modification by drugs. Brit. J. Pharmacol.28, 137–152 (1966).
Alvarez, E. O., Fabra, D.: Prolactin release induced by histamine in maturing male and female rats. J. Neural. Transm.49, 187–195 (1980).
Alvarez, E. O., Donoso, A. O.: Effects of histamine implants in several brain regions on the release of prolactin in conscious adult male rats. J. Endocr.88, 351–358 (1981).
Alvarez, E. O.: Prolactin release induced by H1- or H2-histamine agonists in maturing male and female rats. IRCS Med. Sc.10, 298 (1982 a).
Alvarez, E. O.: Effects of histamine antagonists in the preoptic-anterior hypothalamic area on the prolactin surge induced by ether stress. IRCS Med. Sc.10, 6 (1982 b).
Alvarez, E. O.: Role of histamine in the increased secretion of prolactin induced by ether in adult male rats. J. Endocr.95, 409–415 (1982 c).
Arakelian, M. C., Libertun, C.: H1 and H2-histamine receptor participation in the brain control of prolactin secretion in lactating rats. Endocrinology100, 890–895 (1977).
Baudry, M., Martres, M. P., Schwartz, J. C.: The subcellular localization of histidine decarboxylase in various regions of rat brain. J. Neurochem.21, 1301–1309 (1973).
Black, J. W., Duncan, W. A. M., Durant, C. J., Ganellin, C. R., Parsons, E. M.: Definition and antagonism of histamine H2-receptors. Nature236, 385–390 (1972).
Burkard, W. P.: Histamine H2-receptor binding with3H-cimetidine in brain. Europ. J. Pharmacol.50, 449–450 (1978).
Donoso, A. O., Banzán, A. M., Borzino, M. I.: Prolactin and luteinizing hormone release after intraventricular injection of histamine in rats. J. Endocr.68, 171–172 (1976).
Donoso, A. O., Banzán, A. M.: Acute effects of histamine on plasma prolactin and luteinizing hormone levels in male rats. J. Neural Transm.39, 95–101 (1976).
Donoso, A. O.: Induction of prolactin and luteinizing hormone release by histamine in male and female rats and the influence of brain transmitter antagonists. J. Endocr.76, 193–202 (1978).
Donoso, A. O., Banzán, A. M.: H1- and H2-histamine receptor antagonists and induced release of prolactin in male rats. Neuroendocrinology30, 11–14 (1980).
Falaschi, P., D'Urso, R., Frajese, G., Ruggieri, S., Scarnati, E., Forchetti, C., Agnoli, A.: Dimaprit, a selective histamine H2-receptor agonist, reduces prolactin levels in rats. Acta Endocrinologica Suppl.225, 161 (1979).
Geller, H. M.: Effects of some putative neurotransmitters on unit activity of tuberal hypothalamic neuronsin vitro. Brain Res.108, 423–430 (1976).
Geller, H. M.: Are histamine H2-receptor depression of neuronal activity in tissue cultures from rat hypothalamus mediated through cyclic adenosine monophosphate? Neurosc. Letters14, 49–53 (1979).
Haas, H. L.: Histamine: action on single hypothalamic neurones. Brain Res.76, 363–366 (1974).
Huszti, Z.: Recent status of histamine in the brain. Agents and Actions12, 155–156 (1982).
Kataoka, K., De Robertis, E.: Histamine in isolated small nerve endings and synaptic vesicles of rat brain cortex. J. Pharmacol, exp. ther.156, 114–125 (1967).
Levi, R., Ganellin, C. R., Allan, G., Willens, H. J.: Selective impairment of atrioventricular conduction by 2-(2-pyridil)-ethylamme and 2-(2-thiazolyl)-ethylamine, two histamine H1-receptor agonists. Europ. J. Pharmacol.34, 237–240 (1975).
Libertun, C., McCann, S. M.: The possible role of histamine in the control of prolactin and gonadotropin release. Neuroendocrinology20, 110–120 (1976).
Ojeda, S. R., McCann, S. M.: Development of dopaminergic and estrogenic control of prolactin release in the female rat. Endocrinology95, 1499–1505 (1974).
Palacios, J. M., Schwartz, J. C., Garbarg, M.: High affinity binding of3H-histamine in rat brain. Europ. J. Pharmacol.50, 443–444 (1978).
Pollard, H., Bischoff, S., Schwartz, J. C.: Increased synthesis and release of3H-histamine in rat brain by reserpine. Europ. J. Pharmacol.24, 399–401 (1973).
Renaud, L. P.: Histamine microiontophoresis on identified hypothalamic neurons: 3 patterns of response in the ventromedial nucleus of the rat. Brain Res.115, 339–344 (1976).
Schwartz, J. C.: Minireview: histamine in brain. Life Sci.25, 895–912 (1979).
Singh, V. K., McGeer, E. G.: Binding of3H-histamine to receptor sites in rat brain. Exp. Neurol.66, 413–418 (1979).
Snyder, S. H., Brown, B., Kuhar, M. J.: The subsynaptosomal localization of histamine, histidine decarboxylase and histamine methyl-transferase in rat hypothalamus. J. Neurochem.23, 37–47 (1974).
Steel, R. G. D., Torrie, J. H.: Principles and procedures of statistics. New York: McGraw-Hill. 1960.
Subramanian, N., Whitmore, W. L., Seidler, F. J., Slotkin, T. A.: Ontogeny of histaminergic neurotransmission in the rat brain: Concomitant development of neuronal histamine, H1-receptors, and H1-receptor-mediated stimulation of phospholipid turnover. J. Neurochem.36, 1137–1141 (1981).
Taylor, K. M., Snyder, S. H.: Isotopic microassay of histamine, histidine decarboxylase and histamine methyltransferase in brain tissue. J. Neurochem.19, 1343–1358 (1972).
Taylor, K. M., Snyder, S. H.: The release of histamine from tissues slices of rat hypothalamus. J. Neurochem.21, 1215–1223 (1973).
Wilcox, B. J., Seybold, V. S.: Localization of neural histamine in rat brain. Neurose. Letters29, 105–110 (1982).
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Alvarez, E.O. Induction of prolactin release by H1- or H2-histamine agonists in maturing male and female rats. J. Neural Transmission 59, 241–250 (1984). https://doi.org/10.1007/BF01250011
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DOI: https://doi.org/10.1007/BF01250011