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L-deprenyl plus l-phenylalanine in the treatment of depression

Summary

The antidepressive efficacy of l-deprenyl (5–10 mg daily) plus l-phenylalanine (250 mg/day) has been evaluated in 155 unipolar depressed patients. Both oral and intravenous administration showed beneficial effects in 90% of outpatients and 80.5% of inpatients. It is concluded that this combined treatment has a potent antidepressive action based on the accumulation of l-phenylethylamine in the brain.

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Birkmayer, W., Riederer, P., Linauer, W. et al. L-deprenyl plus l-phenylalanine in the treatment of depression. J. Neural Transmission 59, 81–87 (1984). https://doi.org/10.1007/BF01249880

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  • DOI: https://doi.org/10.1007/BF01249880

Key words

  • Depression syndrome
  • deprenyl
  • phenylalanine
  • antidepressants