Summary
A neurological disease appeared in infant NCS mice during the course of experiments on stunted growth. Signs of uncoordination appeared 5 to 17 days (usually 5 to 7) following oral or parenteral inoculations of infant mice with intestinal or other organ homogenates or filtrates. Death occurred a few hours after the onset of illness. The disease was readily transmitted by oral infection (serial passages) but was not communicable through contact. Weaned mice were not susceptible. Organ homogenates retained activity on filtration through Millipore discs of 0.22 μ but not 0.10 μ. The agent was ether resistant but heat sensitive. The characteristics of the disease are sufficiently different from those produced by the known neurotropic murine viruses to warrant regarding it as a new murine syndrome.
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This work was carried out in the laboratory of Dr.Rene Dubos at the Rockefeller University, New York, N.Y.
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Seravalli, E. Characterization and transmission of an agent producing a neurological disease in infant mice (IMNV). Archiv f Virusforschung 35, 62–69 (1971). https://doi.org/10.1007/BF01249753
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DOI: https://doi.org/10.1007/BF01249753