Zusammenfassung
Bei der Untersuchung erkrankter Babymäuse und klinisch gesunder Muttermäuse des Stammes NMRI wurde mit Hilfe der Gewebekultur aus Gehirn, Herz, Leber, Nieren, Milz, Muskulatur und Darm ein Reo-3-Virus isoliert. Durch die experimentelle Infektion von Babymäusen konnten die identischen Krankheitssymptome in Form von ZNS-Störungen, Wachstumsverzögerungen, Haarveränderungen und Diarrhöe reproduziert werden.
Positive Titer hämagglutinationshemmender und neutralisierender Antikörper wurden sowohl hei gesunden Mäusen konventioneller Zucht als auch bei SPF-Tieren nachgewiesen.
Für eine ätiologische Beteiligung von Reo-3-Viren hei der epizootischen Diarrhöe der Säuglingsmäuse haben sich nach vorliegenden Untersuchungen keine Hinweise ergehen. Nach den klinisch-epizootiologischen Beobachtungen muß jedoch mit dem gleichzeitigen Vorkommen von zwei Erregern gerechnet werden. Die virologischen und serologischen Befunde kennzeichnen die Reo-3-Virusinfektion der Babymäuse als eine enzootische Erkrankung mit hoher Kontagiosität. Den Muttermäusen kommt auf Grund einer persistierenden Infektion eine Bedeutung als Virusüberträger zu.
Summary
A reovirus type 3 was recovered by means of tissue culture from the brain, heart, liver, kidneys, spleen and skeletal muscles of affected suckling mice and clinically health mother mice (strain NMRI). Suckling mice experimentally infected with reovirus type 3 showed signs of a central nervous system disease, retardation of growth, oily hair and diarrhea. Positive hemagglutination-inhibition and neutralizing antibodies were found as well in healthy as in specific-pathogen free animals. No evidence was obtained for an aetiologic relationship between reo-3-infection and epidemic diarrhea of infant mice. The virological and serological results characterize the reo-3-infection of suckling mice as an enzootic disease of high contagiosity. Dams play an important role as carriers due to persistent infections occuring in them.
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Kaaden, O.R., Eißner, G. Untersuchungen zur Reo-3-Infektion der weißen Maus. Archiv f Virusforschung 27, 364–378 (1969). https://doi.org/10.1007/BF01249658
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DOI: https://doi.org/10.1007/BF01249658