Summary
Monkey pox virus (MPV), titrated intramuscularly in cynomolgus monkeys provided a 50 per cent infectivity endpoint of 10−5.8. All infected animals developed monkey pox. Three of 4 sentinel control monkeys developed monkey pox; one experienced subclinical infection. Viremia intervenes between the 4th and 7th days, and may persist for 4 or 5 days post-eruption, even after appearance of HI antibodies. MPV multiplies in the substance of the inoculated muscle. During the pre-eruptive stage of infection this virus is detected earliest in tonsil and spleen, and shortly thereafter in bone marrow and regional lymph nodes. During the early post-eruptive period, in addition to large concentrations of MPV in these same tissues, the virus is regularly found in cutaneous lesions, some-what less regularly in kidney, and very much less regularly in other tissues. Specific antibodies are raised during infection; HI antibodies are less enduring than CF or neutralizing antibodies. Monkeys convalescent from MPV are immune to challenge with vaccinia, but are fully susceptible to Yaba tumor virus.
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This investigation was supported by Public Health Service Research Grant AI06263 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.
Research Career Awardee No. K6-AI-13976, National Institute of Allergy and Infectious Diseases, NIH.
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Wenner, H.A., Cho, C.T., Bolano, C.R. et al. Studies on the pathogenesis of monkey pox. Archiv f Virusforschung 27, 166–178 (1969). https://doi.org/10.1007/BF01249641
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DOI: https://doi.org/10.1007/BF01249641