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Physiological and pathological changes in tissue monoamine oxidase activity

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Summary

This article explores the possibility that malfunction of the enzyme monoamine oxidase (E.C. 1.4.3.4., MAO) could lead to aberrations in the catabolism of biogenic amines in the central nervous system and give rise to certain mental abnormalities. No conclusive evidence could be presented to substantiate this. Data on the normal function of the enzyme (for example its existence in multiple forms, the control of MAO activity by hormones or the independent development of MAO activities towards different substrates during maturation) are reviewed.

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Author notes

  1. M. B. H. Youdim

    Present address: M.R.C. Unit and University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford

Authors and Affiliations

  1. M.R.C. Unit and University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford

    Margarethe Holzbauer

  2. A.R.C. Institute of Animal Physiology, Babraham, Cambridge, Great Britain

    M. B. H. Youdim & Margarethe Holzbauer

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Dedicated to Prof. Dr.W. Birkmayer on the occasion of his 65th birthday.

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Youdim, M.B.H., Holzbauer, M. Physiological and pathological changes in tissue monoamine oxidase activity. J. Neural Transmission 38, 193–229 (1976). https://doi.org/10.1007/BF01249439

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