Summary
The capacity of rabbit IgM and IgG antibody to differentiate various strains of type I poliovirus has been shown not to depend upon the extent of their purification from other serum proteins. IgM and IgG as well as the original sera did not differ from each other in specificity. Comparison of early and hyperimmune sera from the same rabbits did not reveal significant differences in the differentiating capacity of both whole sera and their fractions. The revealed regularities were manifested in different methods of neutralization tests with all poliovirus strains under study. In the course of repeated immunizations the avidity of antibody increases both for the homologous and heterologous strains.
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Pervikov, Y.V., Gracheva, L.A., Voroshilova, M.K. et al. Specificity of rabbit IGM and IGG antibody in intratypic differentiation of poliovirus type I strains. Archiv f Virusforschung 43, 7–13 (1973). https://doi.org/10.1007/BF01249343
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DOI: https://doi.org/10.1007/BF01249343