Summary
5-hydroxytryptamine, when present in the solution bathing the inside surface of bullfrog skin at concentrations of 0.25–25.0 mM, reduced both electrical potential difference and short-circuit current across the skin. The magnitude of reduction in potential difference and short-circuit current was dependent on 5 HT concentration. Reduction in sodium influx entirely accounted for the reduction in short-circuit current. Preliminary evidence suggested a competition between 5 HT and vasopressin in the production of their effects on sodium transport across the skin, while high Ca++ concentrations and 5 HT seemed to act independently of each other.
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Dr. Henry C. and Bertha H. Buswell Fellow.
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Paganelli, C.V., Hong, S.K. Effect of 5-hydroxytryptamine on sodium transport across bullfrog skin. Protoplasma 63, 62–65 (1967). https://doi.org/10.1007/BF01248001
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DOI: https://doi.org/10.1007/BF01248001