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Antidepressants given repeatedly increase the behavioural effect of dopamine D-2 agonist

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Summary

The effects of single or repeated doses of antidepressant drugs (imipramine, amitriptyline, citalopram, mianserin) on rat locomotor hyperactivity induced by quinpirole, a dopamine D-2 receptor agonist, was investigated. Single doses of antidepressants do not change the effect of quinpirole, but enhance it when they are administered repeatedly. This enhancement is inhibited by (±)-sulpiride, a dopamine D-2 receptor antagonist. The results obtained indicate that the enhancement of dopaminergically-stimulated hyperactivity induced by repeated doses of antidepressants is mediated by dopamine D-2 receptors.

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  1. J. Maj

    Present address: Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland

Authors and Affiliations

  1. Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland

    Z. Rogóż, G. Skuza & H. Sowińska

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  1. J. Maj
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  2. Z. Rogóż
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  3. G. Skuza
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  4. H. Sowińska
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Maj, J., Rogóż, Z., Skuza, G. et al. Antidepressants given repeatedly increase the behavioural effect of dopamine D-2 agonist. J. Neural Transmission 78, 1–8 (1989). https://doi.org/10.1007/BF01247108

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  • DOI: https://doi.org/10.1007/BF01247108

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