Journal of Neural Transmission

, Volume 64, Issue 2, pp 93–103 | Cite as

L-DOPA reverses the elevated density of D2 dopamine receptors in Parkinson's diseased striatum

  • M. Guttman
  • P. Seeman
Original Papers


Striatal dopamine receptors were studied using [3H]-spiperone in postmortem tissues of thirty-six patients with Parkinson's Disease. Each tissue was analyzed by the receptor saturation method. In non-treated patients, the D2 dopamine receptor density was elevated in the caudate nucleus and putamen compared to controls. In L-DOPA-treated patients, the receptor density was the same as controls. The dissociation constant for [3H]-spiperone was similar in all groups. The elevated density of D2 receptors in non-treated patients may indicate dopaminergic supersensitivity in this disease. The elevated density was reversed with dopamine agonist therapy, but the density was not lower than control tissues.


Dopamine Agonist Caudate Nucleus Receptor Density Striatal Dopamine Agonist Therapy 
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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • M. Guttman
    • 1
  • P. Seeman
    • 2
  1. 1.Department of MedicineUniversity of TorontoTorontoCanada
  2. 2.Department of PharmacologyUniversity of TorontoTorontoCanada

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