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Tacaribe virus infection of guinea-pig

Virus distribution, appearance of antibodies and immunity against Junin virus infection

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Summary

Guinea-pigs were inoculated with live Tacaribe virus by the intramuscular route. For a period of 48 days after inoculation infectious virus was isolated from lymph nodes, but not consistently. Virus is present in serum on the 7th day and in liver on the 13th day.

There is no immunity against challenge with Junin virus in the first 3 days. Partial resistance appears after 7 days and complete immunity afterwards.

The complement fixing antibodies against Tacaribe and Junin viruses are detected on the 13th day. The antibody titer is higher against the homologous antigen.

The mechanism of the immunity against Junin virus infection after Tacaribe virus inoculation is discussed.

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References

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Author notes

  1. Celia E. Coto

    Present address: Facultad de Ciencias Médicas, Instituto de Microbiología y Parasitologia, Buenos Aires, Argentina

Authors and Affiliations

  1. Facultad de Ciencias Médicas, Instituto de Microbiología y Parasitologia, Buenos Aires, Argentina

    Edith Rey & A. S. Parodi

Authors
  1. Celia E. Coto
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  2. Edith Rey
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  3. A. S. Parodi
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Additional information

This paper has been supported in part by a grant of NIH from U.S. No. E 4753 y por la Comisión de Lucha contra la Fiebre Hemorrágica Argentina del Ministerio de Asistencia Social y Salud Pública de la República Argentina.

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Coto, C.E., Rey, E. & Parodi, A.S. Tacaribe virus infection of guinea-pig. Archiv f Virusforschung 20, 81–86 (1967). https://doi.org/10.1007/BF01245771

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  • DOI: https://doi.org/10.1007/BF01245771

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