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Simulation of genetic systems

XI. Normalizing selection

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Summary

The effects of intense normalizing selection have been studied, using computer simulation, for models of 3, 4, 5, 6, 8, 12 and 24 loci. The effectiveness of such selection in reducing heterozygosity decreases with increase of the number of loci to a limit that is only slightly greater than that consequent from random genetic dispersion, if the loci are freely recombining. Tight linkage markedly reduces the rate of loss of heterozygosity for small numbers of loci, but this effect of tight linkage decreases with increase of the number of loci.

Zusammenfassung

Es wird die Wirkung normalisierender Selektion für 3, 4, 5, 6, 8, 12 und 24 Loci unter Verwendung von Computer-Simulationen untersucht. Die Wirksamkeit derartiger Selektion hinsichtlich der Reduzierung der Heterozygotie nimmt mit zunehmender Zahl der Loci bis zu einem Grenzwert ab, der nur größer ist als der aus zufällinger genetischer Dispersion folgende, wenn die Loci frei miteinander Rekombinieren. Enge Koppelung reduziert die Rate des Heterozygotenverlustes bei kleiner Zahl von Loci beträchtlich, jedoch nimmt dieser Effekt der engen Koppelung mit steigender Zahl der Loci ab.

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Author notes

  1. Alex Fraser

    Present address: Biological Sciences Department, University of Cincinnati, 45202, Cincinnati, Ohio

Authors and Affiliations

  1. Department of Animal Husbandry, University of California, Davis

    Ross Allen & Alex Fraser

Authors
  1. Ross Allen
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  2. Alex Fraser
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Additional information

This research was supported by NIH Grant GM-11778.

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Allen, R., Fraser, A. Simulation of genetic systems. Theoret. Appl. Genetics 38, 223–225 (1968). https://doi.org/10.1007/BF01245621

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  • DOI: https://doi.org/10.1007/BF01245621

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