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Demonstration of human motor cortex activation using SPECT

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Summary

Recent advances in single photon emission computed tomography (SPECT) have allowed improved image resolution with lower doses of labelled tracer. Capitalizing on these improvements, the authors have developed a new SPECT protocol for imaging neuronal activation. We outline this technique and describe how it can demonstrate increased human motor cortex activity in normal subjects performing a motor task. The ability to accurately demonstrate neuronal activation with SPECT using this method may have important scientific and clinical implications.

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Author notes

  1. M. S. George

    Present address: Biological Psychiatry Branch, National Institute of Mental Health, 9000 Rockville Pike, Building 10, Room 3N212, 20892, Bethesda, MD, USA

Authors and Affiliations

  1. Institute of Nuclear Medicine, University College and Middlesex School of Medicine (UCMSM), London

    D. C. Costa, K. Kouris & P. J. Ell

  2. Raymond Way Neuropsychiatry Research Group, Department of Clinical Neurology, Institute of Neurology, Queen Square, London, UK

    M. S. George & H. A. Ring

  3. Department of Psychiatry and Behavioural Sciences, Medical University of South Carolina, Charleston, SC, USA

    M. S. George

  4. Department of Nuclear Medicine, Kuwait University, Kuwait

    K. Kouris

Authors
  1. M. S. George
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  2. H. A. Ring
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  3. D. C. Costa
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  4. K. Kouris
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  5. P. J. Ell
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George, M.S., Ring, H.A., Costa, D.C. et al. Demonstration of human motor cortex activation using SPECT. J. Neural Transmission 87, 231–236 (1992). https://doi.org/10.1007/BF01245369

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  • DOI: https://doi.org/10.1007/BF01245369

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