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Further evidence for a correlation between EEG synchronization and plasma DBH activity in normal subjects

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Summary

In a former investigation we had got evidence for a relationship between synchronization of the resting EEG and plasma dopamine-β-hydroxylase (DBH) activity in healthy males. In order to substantiate this finding we now examined a new sample of males and a sample of females, both with either low-voltage or monotonous alpha-EEGs, and relatives of probands with either EEG type. In the new sample of males, the carriers of a low-voltage EEG (n=15) again had significantly lower plasma DBH activity than the subjects with a monotonous alpha-EEG (n=16). In females there was no difference. In the families of probands with a monotonous alpha-EEG the relatives carrying the trait significantly exceeded non-trait-carriers in DBH activity. This effect is mainly due to the male subjects, confirming the results in the proband groups. Presumably there are common genetic factors that contribute to the variability of both the EEG and DBH.—Taking into account experimental findings on central catecholaminergic activity and EEG synchronization, a hypothesis on the mechanisms that are responsible for the relationship is proposed.

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References

  • Candy, J. M., Key, B. J. A presynaptic site of action within the mesencephalic reticular formation for (+)-amphetamine-induced electrocortical desynchronization. Brit. J. Pharmacol.61, 331–338 (1977).

    Google Scholar 

  • Eshel, Y., Korczyn, A. D., Rabinowitz, R., Gitter, S. The stability of dopamine-beta-hydroxylase activity in blood samples. Clin. Chim. Acta82, 291–292 (1978).

    PubMed  Google Scholar 

  • Geffen, L. Serum dopamine-beta-hydroxylase as an index of sympathetic function. Life Sci.14, 1593–1604 (1974).

    PubMed  Google Scholar 

  • Heuschert, D. EEG-Untersuchungen an eineiigen Zwillingen in höherem Lebensalter. Zschr. menschl. Vererb. Konstitut.-Lehre37, 128–172 (1963).

    Google Scholar 

  • Juel-Nielsen, N., Harvald, B. The electroencephalogram in uniovular twins brought up apart. Acta Genet. Statist. Med.8, 57–64 (1958).

    PubMed  Google Scholar 

  • Jung, R. Neurophysiologische Untersuchungsmethoden. In: Handbuch der Inneren Medizin, B. V/1, pp. 1206–1420. Berlin-Göttingen-Heidelberg: Springer. 1953.

    Google Scholar 

  • Keane, P. E., Candy, J. M., Bradley, P. B. The role of endogenous catecholamines in the regulation of electrocortical activity in the encéphale isolé cat. Electroenceph. Clin. Neurophysiol.41, 561–570 (1976).

    PubMed  Google Scholar 

  • Key, B. J. Electrocortical changes induced by perfusion of catecholamines into the brain stem reticular formation. Neuropharmacology14, 41–51 (1975).

    PubMed  Google Scholar 

  • Key, B. J., Krzywoskinski, L. Electrocortical changes induced by the perfusion of noradrenaline, acetylcholine and their antagonists directly into the dorsal raphe nucleus of the cat. Brit. J. Pharmacol.61, 297–305 (1977).

    Google Scholar 

  • Kopun, M., Herschel, M. Determination of dopamine-beta-hydroxylase activity by means of chromatogram-spectrofluorometric measurement in remission. Analyt. Biochem.85, 556–563 (1978).

    PubMed  Google Scholar 

  • Kostowski, W., Gumulka, S. Injections of some drugs affecting cholinergic and catecholaminergic neurons into the pontine raphe area: effects on EEG pattern. Pol. J. Pharmacol. Pharm.26, 351–368 (1974).

    PubMed  Google Scholar 

  • Lamprecht, F., Andres, R., Kopin, I. J. Serum dopamine-beta-hydroxylase: constancy of levels in normotensive adults and decreases with development of blood pressure elevation. Life Sci.17, 749–754 (1975).

    PubMed  Google Scholar 

  • Lennox, W. G., Gibbs, F. A., Gibbs, E. L. The brain wave pattern, an hereditary trait. Evidence from 74 “normal” pairs of twins. J. Hered.36, 233–243 (1945).

    Google Scholar 

  • Lykken, D. T., TeLlegen, A., Thorkelson, K. Genetic determination of EEG frequency spectra. Biol. Psychol.1, 245–259 (1974).

    PubMed  Google Scholar 

  • Moore, R. Y., Bloom, F. E. Central catecholamine neuron systems: anatomy and physiology of the norepinephrine and epinephrine systems. Ann. Rev. Neurosci.2, 113–168 (1979).

    PubMed  Google Scholar 

  • Nagatsu, T., Kato, T., Numata, Y., Ikuta, K., Sano, M., Nagatsu, I., Takeuchi, T., Matsuzaki, M., Umezawa, H. Correlation between serum dopamine-beta-hydroxylase activity and dopamine-beta-hydroxylase and tyrosine hydroxylase activities in central and peripheral adrenergic neurons and adrenal glands. Experientia33, 581–583 (1977).

    PubMed  Google Scholar 

  • Nagatsu, T., Udenfriend, S. Photometric assay of dopamine-beta-hydroxylase activity in human blood. Clin. Chem.18, 980–983 (1972).

    PubMed  Google Scholar 

  • Propping, P. Genetic control of ethanol action on the central nervous system. An EEG study in twins. Hum. Genet.35, 309–334 (1977).

    PubMed  Google Scholar 

  • Propping, P., Friedl, W., Nebel, B., Feige, A. Plasma DBH, platelet MAO and proteins of red blood cell membranes in individuals with variants of the normal EEG. Neuropsychobiol.5, 309–316 (1979).

    Google Scholar 

  • Propping, P., Krüger, J., Janah, A. Effect of alcohol on genetically determined variants of the normal EEG. Psychiat. Res.2, 85–98 (1980).

    Google Scholar 

  • Saavedra, J. M., Zivin, J. Tyrosine hydroxylase and dopamine-beta-hydroxylase: distribution in discrete areas of the rat limbic system. Brain Res.105, 517–524 (1976).

    PubMed  Google Scholar 

  • Sauter, A. M., Lew, J. Y., Baba, Y., Goldstein, M. Effect of phenylethanol-amine N-methyltransferase and dopamine-beta-hydroxylase inhibition on epinephrine levels in the brain. Life Sci.21, 261–266 (1977).

    PubMed  Google Scholar 

  • Vogel, F. Über die Erblichkeit des normalen Elektroencephalogramms. Stuttgart: G. Thieme. 1958.

    Google Scholar 

  • Vogel, F. The genetic basis of the normal human electroencephalogram (EEG). Humangenetik10, 91–114 (1970).

    PubMed  Google Scholar 

  • Vogel, F., Schalt, E. The electroencephalogram (EEG) as a research tool in human behavior genetics: psychological examinations in healthy males with various inherited EEG variants. III. Interpretation of the results. Hum. Genet.47, 81–111 (1979 a).

    PubMed  Google Scholar 

  • Vogel, F., Schalt, E., Krüger, J. The electroencephalogram (EEG) as a research tool in human behavior genetics: psychological examinations in healthy males with various inherited EEG variants. II. Results. Hum. Genet.47, 47–80 (1979 b).

    PubMed  Google Scholar 

  • Vogel, F., Schalt, E., Krüger, J., Propping, P., Lehnert, K. F. The electroencephalogram (EEG) as a research tool in human behavior genetics: psychological examinations in healthy males with various inherited EEG variants. I. Rationale of the study; material; methods; heritability of test parameters. Hum. Genet.47, 1–45 (1979 c).

    PubMed  Google Scholar 

  • Weinshilboum, R. M. Serum dopamine-beta-hydroxylase. Pharmacol. Rev.30, 133–166 (1979).

    Google Scholar 

  • Weinshilboum, R. M., Raymond, F. A., Elveback, L. R., Weidman, W. H. Serum dopamine-beta-hydroxylase activity: sibling-sibling correlation. Science181, 943–945 (1973).

    PubMed  Google Scholar 

  • Young, J. P., Lader, M. H., Fenton, G. W. A twin study of the genetic influences on the electroencephalogram. J. Med. Genet.9, 13–16 (1972).

    PubMed  Google Scholar 

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  1. P. Propping

    Present address: Institut für Humangenetik, Universität Heidelberg, Federal Republic of Germany

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  1. Institut für Humangenetik, Universität Heidelberg, Federal Republic of Germany

    Waltraut Friedl & R. Pluto

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  1. P. Propping
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  2. Waltraut Friedl
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  3. R. Pluto
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Supported by Deutsche Forschungsgemeinschaft.

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Propping, P., Friedl, W. & Pluto, R. Further evidence for a correlation between EEG synchronization and plasma DBH activity in normal subjects. J. Neural Transmission 49, 167–178 (1980). https://doi.org/10.1007/BF01245222

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  • DOI: https://doi.org/10.1007/BF01245222

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