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Effect of chronic haloperidol treatment on peripheral benzodiazepine binding sites in cerebral cortex of rats

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Summary

The effects of 21 days of haloperidol treatment on central benzodiazepine (BZ) receptors in the cerebral cortex of rats and on peripheral-type BZ binding sites (PBS) in the cerebral cortex and heart of rats were studied. Neuroleptic treatment did not affect the maximal binding capacity or the affinity of the central BZ receptor to3H-flunitrazepam. Chronic haloperidol treatment resulted in a significant increase of 38% in PBS density in the cerebral cortex, with no alteration in PBS density in the heart. No alteration in PBS affinity for its ligand3H-PK 11195 was observed, either in the cerebral cortex or in the heart. The modulatory effect of chronic haloperidol administration on PBS density in the brain may be related to some of the neurobehavioral or hormonal effects of the drug.

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Author notes

  1. M. Gavish

    Present address: Rappaport Family Institute for Research in the Medical Sciences and Department of Pharmacology, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa

Authors and Affiliations

  1. Rappaport Family Institute for Research in the Medical Sciences and Department of Pharmacology, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa

    D. Becker & Z. Tanne

  2. Hasharon Hospital, Petah Tiqva

    R. Weizman

  3. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

    R. Weizman

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  1. M. Gavish
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  2. R. Weizman
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  3. D. Becker
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  4. Z. Tanne
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Gavish, M., Weizman, R., Becker, D. et al. Effect of chronic haloperidol treatment on peripheral benzodiazepine binding sites in cerebral cortex of rats. J. Neural Transmission 74, 109–116 (1988). https://doi.org/10.1007/BF01245144

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  • DOI: https://doi.org/10.1007/BF01245144

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