Summary
Depolarizing stimuli increase the release of neurotransmitter met-enkephalin from rat striatal slices. Bay K 8644, a calcium agonist, significantly enhances the submaximal release of this peptide. Several organic calcium antagonists, including nimodipine, nifedipine, nicardipine, gallopamil and flunarizine, are able to inhibit the potassium-evoked met-enkephalin release both in vitro and ex vivo. The data suggest that the release of this neuropeptide is modulated by calcium antagonist-sensitive calcium channels.
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Govoni, S., Goss, I., Di Giovine, S. et al. Calcium antagonists inhibit met-enkephalin immunoreactive material release: in vitro and ex vivo experiments. J. Neural Transmission 80, 1–8 (1990). https://doi.org/10.1007/BF01245019
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DOI: https://doi.org/10.1007/BF01245019