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Chronic imipramine “reverses” B-HT 920-induced hypomotility in rats

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Summary

B-HT 920, a selective DA autoreceptor agonist, reduced motor activity in rats. Chronic, but not acute, treatment with imipramine (IMI) reversed this effect. The mechanism by which chronic IMI reverses the B-HT 920 effect is discussed.

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Author notes

  1. G. Serra

    Present address: Department of Neuroscience “B. B. Brodie”, University of Cagliari, Cagliari, Italy

Authors and Affiliations

  1. Department of Neuroscience “B. B. Brodie”, University of Cagliari, Cagliari, Italy

    M. Collu, P. S. D'Aquila & G. L. Gessa

  2. Institute of Pharmacology and Biochemical Pathology, University of Cagliari, Cagliari, Italy

    G. M. De Montis

Authors
  1. G. Serra
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  2. M. Collu
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  3. P. S. D'Aquila
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  4. G. M. De Montis
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  5. G. L. Gessa
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Serra, G., Collu, M., D'Aquila, P.S. et al. Chronic imipramine “reverses” B-HT 920-induced hypomotility in rats. J. Neural Transmission 84, 237–240 (1991). https://doi.org/10.1007/BF01244974

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  • DOI: https://doi.org/10.1007/BF01244974

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