Sexual differences in sensitivity to methamphetamine toxicity

  • G. C. Wagner
  • T. L. Tekirian
  • C. T. Cheo
Short Communication


Male and female mice were treated with methamphetamine (10.0 mg/kg/injection for four injections) and sacrificed two weeks later. It was observed that the methamphetamine treatment caused depletions in striatal dopamine which were significantly greater in males (74%) than in females (56%). These results indicate that estrogen may have a protective effect against methamphetamine-induced dopamine depletions and may relate to the fact that males are more likely to incur Parkinson's disease than females.


Methamphetamine Parkinson's sex dopamine 


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  1. Becker JB (1990) Direct effect of 17β-estradiol on striatum: sex differences in dopamine release. Synapse 5: 157–164Google Scholar
  2. Becker JB, Ramirez VD (1980) Sex differences in the amphetamine and stimulated release of catecholamines from rat striatal tissue in vitro. Brain Res 204: 361–372Google Scholar
  3. Brooks WJ, Jarvis MF, Wagner GC (1989) Influence of sex, age, and strain of MPTP-induced neurotoxicity. Res Comm Subst Abuse 10: 181–184Google Scholar
  4. De Vito M, Wagner GC (1989) Methamphetamine-induced neuronal damage: a possible role for free radicals. Neuropharmacology 28: 1145–1150Google Scholar
  5. Holzbauer M, Youdim MBH (1973) The oestrus cycle and monoamine oxidase activity. Br J Pharmacol 48: 600–628Google Scholar
  6. Johnson SK, Medina D, Wagner GC (1992) The effects of deprenyl on methamphetamineinduced dopamine depletions. J Neural Transm [Gen Sect] 89: 123–127Google Scholar
  7. Li J (1966) Statistical inference. Edwards Brothers Inc, Ann Arbor, pp 548–552Google Scholar
  8. Lillienfeld D (1990) Two decades of increasing mortality from Parkinson's disease among the US elderly. Arch Neurol 47: 731–734Google Scholar
  9. Seiden LS, Vosmer G (1984) Formation of 6-hydroxydopamine in caudate nucleus of the rat brain after a single dose of methylamphetamine. Pharmacol Biochem Behav 21: 29–31Google Scholar
  10. US Department of Health and Human Services-Public Health Service (1988) Vital statistics of the United States. Mortality, vol IIAGoogle Scholar
  11. Wagner GC, Walsh SL (1991) Evaluation of the effects of inhibition of monoamine oxidase and senescence on methamphetamine-induced neuronal damage. Int J Dev Neurosci 9: 171–174Google Scholar
  12. Wagner GC, Seiden LS, Schuster CR (1979) Methamphetamine-induced changes in brain catecholamines in rats and guinea pigs. Drug Alcohol Depend 4: 435–438Google Scholar
  13. Wagner GC, Ricaurte GA, Seiden LS, Schuster CR, Miller RJ, Westley J (1980) Longlasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine. Brain Res 181: 151–160Google Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • G. C. Wagner
    • 1
  • T. L. Tekirian
    • 1
  • C. T. Cheo
    • 1
  1. 1.Department of PsychologyRutgers UniversityNew BrunswickUSA

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