Sexual differences in sensitivity to methamphetamine toxicity

  • G. C. Wagner
  • T. L. Tekirian
  • C. T. Cheo
Short Communication

Summary

Male and female mice were treated with methamphetamine (10.0 mg/kg/injection for four injections) and sacrificed two weeks later. It was observed that the methamphetamine treatment caused depletions in striatal dopamine which were significantly greater in males (74%) than in females (56%). These results indicate that estrogen may have a protective effect against methamphetamine-induced dopamine depletions and may relate to the fact that males are more likely to incur Parkinson's disease than females.

Keywords

Methamphetamine Parkinson's sex dopamine 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • G. C. Wagner
    • 1
  • T. L. Tekirian
    • 1
  • C. T. Cheo
    • 1
  1. 1.Department of PsychologyRutgers UniversityNew BrunswickUSA

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