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Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors

  • E. Schlicker
  • K. Fink
  • M. Detzner
  • M. Göthert
Full Papers

Summary

In superfused mouse striatal slices preincubated with [3H] dopamine 25 nmol/l, the electrically (3 Hz) evoked tritium overflow was inhibited by histamine 10 μmol/l by 18%. The degree of inhibition was increased to 38% by haloperidol but not affected by (1) atropine, (2) reducing the stimulation frequency to 0.3 Hz or (3) increasing the concentration of [3H]dopamine (used for preincubation) to 100 nmol/l. The effect of histamine was mimicked by the H3 agonist R-(−)-α-methylhistamine; it was not affected by the H1 antagonist dimetindene and the H2 antagonist ranitidine but abolished by the H3 antagonist thioperamide. Tritium overflow evoked by Ca2+ ions (introduced into Ca2+free, K+-rich medium containing tetrodotoxin) was not affected by histamine 10 μmol/l in the absence, but inhibited (by 30%) in the presence of haloperidol; the effect of histamine was abolished by thioperamide. In conclusion, the dopaminergic nerve terminals in the mouse striatum are endowed with presynaptic H3 receptors. Simultaneous blockade of dopamine autoreceptors increases the extent of the H3 receptor-mediated inhibition of dopamine release.

Keywords

Presynaptic H3 receptors dopamine release mouse striatal slices thioperamide R-(−)-α-Methylhistamine 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • E. Schlicker
    • 1
  • K. Fink
    • 1
  • M. Detzner
    • 1
  • M. Göthert
    • 1
  1. 1.Institut für Pharmakologie und ToxikologieRheinische Friedrich-Wilhelms-UniversitätBonnFederal Republic of Germany

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