Abstract
Sample preparation is the critical step in analysis of residues in biological samples. The development of a ragged method is time-consuming, because a huge number of parameters must be checked. To reduce the number of experiments Taguchi's method was applied in the sample preparation of metabolites of albendazole. During the experiments 11 controllable and 7 noise factors were investigated. From the influence of controllable and noise factors on recovery and standard deviation, conditions for the sample preparation and recovery could be concluded with high accuracy and reliability.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
G. Wernimont,ASTM Standardization News 1977, p. 13.
M. S. Phadke, Quality Engineering Using Robust Design, Prentice-Hall International, Inc. 1989
J. F. Rossignol, H. Maisonneuve,Trans. R. Soc. Trop. Med. Hyg. 1983,77, 707.
A. Davis et al.,Bull. Wld Hlth Org. 1986,64, 383.
R. J. Gyurik, A. W. Chow, B. Zaber, E. L. Brunner, J. A. Miller, A. J. Villani, L. A. Petka, R. C. Parish,Am. Soc. for Pharm. and Exp. 1981,Ther. 9, 503.
A. M. Marti, A. E. Mooser, H. Koch,J. Chromatogr. 1990,498, 145.
R. T. Wilson, J. M. Groneck, A. C. Henry, L. D. Rowe,J. Assoc. Off. Anal. Chem. 1991,74, 56.
J. Markus, J. Sherma, J. AOAC Int.1992,75, 1129.
S. A. Barker, T. McDowell, B. Charkhian, L. C. Hsieh, C. R. Short,J. Assoc. Off. Anal. Chem. 1990,73, 22.
A. R. Long, L. C. Hsieh, M. S. Malbrough, C. R. Short, S. A. Barker,J. Assoc. Off. Anal. Chem. 1989,72, 739.
A. Macri, G. Brambilla, C. Civitareale, A. Bocca,Ital. J. Food Sci. 1993,3, 239.
P. S. Chu, R. Y. Wang, T. A. Brandt, C. A. Weerasinghe,J. Chromatogr. 1993,620, 129.
Zs. Romvári, J. Fekete, S. Kemény, Gy. Pokol, Determination of two metabolites of albendazole using a HPLC method,Chromatographia (to be published).
G. E. P. Box and discussions afterwards,Technometrics. 1988,30, 1.
V. N. Nair and discussions afterwards,Technometrics. 1992,34, 127.
D. C. Montgomery, Design and Analysis of Experiments, Wiley New York 1991.
C. Daniel and discussions afterwords;Technometrics. 1959,149, 1.
C. Daniel, Application of Statistics to Industrial Experimentation, Wiley, New York, 1976.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Romvári, Z., Kemény, S., Pokol, G. et al. A new approach for development of rugged sample preparation of metabolites of albendazole in cow milk. Mikrochim Acta 130, 155–163 (1999). https://doi.org/10.1007/BF01244922
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01244922