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On the origin of homovanillic acid (HVA) in the cerebrospinal fluid

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Summary

The contribution of homovanillic acid by the caudate nuclei to the cerebrospinal fluid has been assessed quantitatively on the basis of available clinical-neurochemical and animal-experimental data. A considerable fraction of the caudatal tissue may be involved in this function.

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References

  • Bernheimer, H., K. Jellinger, F. Seitelberger, W. Birkmayer, andO. Horny-kiewicz: Unpublished data, 1972; cited byHornykiewicz, 1973.

  • Blinkov, S. M., andI. I. Glezer: The human brain in figures and tables. A quantitative handbook. New York: Basic Books, Plenum Press. 1968. (Original Russian text published in Leningrad in 1964. Translated from the Russian byHaigh, B.)

    Google Scholar 

  • Elliott, H. C.: Textbook of neuroanatomy. Philadelphia-Montreal: J. B. Lippincott. 1963.

    Google Scholar 

  • Frontera, J. G.: Evaluation of the immediate effects of some fixatives upon the measurements of the brains of macaques. J. Comp. Neurol.109, 417–438 (1958).

    Google Scholar 

  • Garelis, E., andT. L. Sourkes: The sites of origin in the central nervous system of monoamine metabolites measured in human cerebrospinal fluid. J. Neurol. Neurosurg. and Psychiat. (in press, 1973).

  • Hornykiewicz, O.: Dopamine (3-hydroxytyramine) and brain function. Pharmacol. Rev.18, 925–964 (1966).

    Google Scholar 

  • Hornykiewicz, O.: Mechanism of action of levodopa in parkinsonism. In: The treatment of parkinson's disease —The role of dopa decarboxylase inhibitors (Yahr, M. D., ed.). New York: Raven Press. 1973.

    Google Scholar 

  • Javoy, F., Y. Agid, D. Bouvet, andJ. Glowinski: Feedback control of dopamine synthesis in dopaminergic terminals of the rat striatum. J. Pharmacol. Exp. Ther.182, 454–463 (1972).

    Google Scholar 

  • Kappers, J. A.: Structural and functional changes in the telencephalic choroid plexus during human ontogenesis. In: The cerebrospinal fluid (Wolstenholme, G. E. W., andC. M. O'Connor, eds.), pp. 3–25. London: Churchill. 1958.

    Google Scholar 

  • Katzman, R.: Blood-brain-CSF barriers. In: Basic neurochemistry (Albers, R. W., G. J. Siegel, R. Katzman, andB. W. Agranoff, eds.), p. 334. Boston: Little, Brown & Co. 1972.

    Google Scholar 

  • Knudsen, P. A.: Ventrikeles atorrelsesforhold: anatomisk normale hjerner fra voksne mennsker. Odense. 1958. (Quoted byBlinkov andGlezer, 1968, p. 135 ff.)

  • Lancaster, G., L. Larochelle, P. Bédard, K. Missala, T. L. Sourkes, andL. J. Poirier: Effect of brain lesions and of harmaline on the dopadecarboxylase activity of striatum of the cat. J. Neurol. Sci.11, 265–274 (1970).

    Google Scholar 

  • Papeschi, R., P. Molina-Negro, T. L. Sourkes, andG. Erba: The concentration of homovanillic and 5-hydroxyindoleacetic acids in ventricular and lumbar CSF. Neurol.22, 1151–1159 (1972).

    Google Scholar 

  • Portig, P. J., andM. Vogt: Release into the cerebral ventricles of substances with possible transmitter function in the caudate nucleus. J. Physiol. (London)204, 687–715 (1969).

    Google Scholar 

  • Sourkes, T. L.: Enzymology and sites of action of monoamines in the CNS. In: The treatment of parkinson's disease —the role of dopa decarboxylase inhibitors (Yahr, M. D., ed.), pp. 13–36. New York: Raven Press. 1973.

    Google Scholar 

  • Spano, P. F., andN. H. Neff: Metabolic fate of caudate nucleus dopamine. Brain Res.42, 139–145 (1972).

    Google Scholar 

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Sourkes, T.L. On the origin of homovanillic acid (HVA) in the cerebrospinal fluid. J. Neural Transmission 34, 153–157 (1973). https://doi.org/10.1007/BF01244668

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  • DOI: https://doi.org/10.1007/BF01244668

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