Summary
The levels of pineal and serum melatonin at mid-light and mid-dark of male rats under a photoperiod of 12 h light: 12 h darkness with age ranging from day 1 to day 42 postpartum were determined. At mide-dark, pineal melatonin levels were found to increase with age; when the body weight was considered, an early developmental rise (1-to-9-day old), an active period (11-to 17-day old), and a period of lower levels (after 21-day-old) were noted. Serum melatonin levels at mid-dark showed similar changes to the latter.
At mid-light, this pattern of change was also present in pineal melatonin contents relative to body weight but was absent in serum melatonin levels.
Our study indicated that weaning was not responsible for the pre-pubertal decline in pineal melatonin secretion. It was suggested that these changes in the secretory pattern of pineal melatonin may play a role in the development of the reproductive system in rats.
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References
Arendt J (1985) Mammalian pineal rhythm. In: Reiter RJ (ed) Pineal research reviews, vol 3. Alan R Liss, New York, pp 161–213
Arishima K, Kiuchi M, Yamamoto M, Eguchi Y, Mochizuki K (1984) Evidence for no relationship of the pineal activity with the neonatal shrinkage of Leydig cells in the rat. Experientia 40: 1155–1157
Axelrod J, Fraschini F, Velo GP (1983) The pineal gland and its endocrine role. Plenum, New York, pp 1–604
Binkley S, Brammer M (1982) Development of daily cycles in the pineal gland. In: Klein DC (ed) Melatonin rhythm generating system. Karger, Basel, pp 259–272
Birau N, Schloot W (1981) Melatonin-current status and perspectives. Pergamon, Oxford, pp 1–410
Bittman EL, Dempsey RJ, Karsch FJ (1983) Pineal melatonin secretion drives the reproductive response to day length in the ewe. Endocrinology 113: 2276–2283
Brown GM, Wainwright SD (1985) The pineal gland: endocrine aspects. Pergamon, Oxford, pp 1–367
Brown GM, Seggie J, Grota LJ (1985) Serum melatonin response to melatonin administration in the Syrian hamster. Neuroendocrinology 41: 31–35
Bubenik GA, Brown GM, Grata LJ (1976) Differential localization of N-acetylated indolealkylamines in CNS and Harderian gland using immunohistology. Brain Res 118: 417–427
Debeljuk L (1969) Effect of melatonin on the gonadotrophic function of the male rat under constant illumination. Endocrinology 84: 937–940
Ellison N, Weller JL, Klein DC (1972) Development of a circadian rhythm in the activity of pineal serotonin N-acetyltransferase. J Neurochem 19: 1335–1341
Erdinc F (1977) Concrement formation encountered in the rat pineal gland. Experientia 33: 514
Erlich SD, Apuzzo MLJ (1985) The pineal gland: anatomy, physiology, and clinical significance. J Neurosurg 63: 321–341
Grota LJ, Snieckus V, de Silva SO, Tsui HW, Holloway WR, Lewy AJ, Brown GM (1981) Radioimmunoassay of melatonin in rat serum. Prog Neuropsychopharmacology 5: 523–526
Kerenyi NA, Sarkar K (1968) The postnatal transformation of the pineal gland. Acta Morphol Hung 16: 223–236
Kinson GA, Peat F (1971) The influences of illuminatin, melatonin, and pinealectomy on testicular function in the rat. Life Sci 10: 259–269
Klein DC (1982) Melatonin rhythm generating system. Karger, Basel pp 1–250
Klein DC, Namboodiri MAA, Auerbach DA (1981) The melatonin rhythm generating system: developmental aspects. Life Sci 28: 1975–1986
Klein DC, Smoot R, Weller JL, Higa S, Markey SP, Creed GJ, Jacobowitz DM (1983) Lesion of the paraventricular nucleus area of the hypothalamus disrupt the suprachiasmatic spinal cord circuit in the melatonin rhythm generating system. Brain Res Bull 10: 641–652
Lang U, Aubert ML, Conne BS, Bradtke JC, Sizonenko PC (1983) Influence of exogenous melatonin on melatonin secretion and the neuroendocrine reproductive axis of intact male rats during sexual maturation. Endocrinology 112: 1578–1584
Lerner AB, Case JD, Takahaski Y, Lee TH, Mori W (1958) Isolation of melatonin, the pineal gland factor that lightens melanocytes. J Am Chem Soc 80: 2587
Lerner AB, Case JD, Heinzelman RV (1959) Structure of melatonin. J Am Chem Soc 81: 6084–6085
Martin JE (1982) Melatonin effects on pituitary function during development. In: Klein DC (ed) Melatonin rhythm generating system. Karger, Basel, pp 232–250
Pang SF (1985) Melatonin concentrations in blood and pineal gland. In: Reiter RJ (ed) Pineal research reviews, vol 3. Alan R Liss, New York, pp 115–159
Pang SF, Brown GM, Grota LJ, Chambers JW, Rodman RL (1977) Determination of N-acetylserotonin and melatonin activities in the pineal gland, retina, Harderian gland, brain and serum of rats and chickens. Neuroendocrinology 23: 1–13
Pang SF, Huang CY, Ng MT, He ZC (1985) Plasma concentrations of melatonin and N-acetylserotonin in different age groups of human males. Acta Physiol Sinica 37: 492–496
Pang SF, Tang F, Tang PL (1984) Negative correlation of age and the levels of pineal melatonin, pineal N-acetylserotonin, and serum melatonin in male rats. J Exp Zool 229: 41–47
Quay WB (1974) Pineal chemistry. Charles C Thomas, Springfield, pp 1–430
Ralph CL (1980) Melatonin production by extra-pineal tissues. In: Birau S, Brammer M (eds) Melatonin-current status and perspectives. Pergamon, Oxford, pp 35–46
Reiter RJ (1981) The pineal gland, vol 2, reproductive effects. CRC, Boca Raton, pp 1–227
Reiter RJ (1981) The pineal gland, vol 3, extra-reproductive effects. CRC, Boca Raton, pp 1–240
Reiter RJ, Ellison NM (1970) Delayed puberty in blinded, anosmic female rats: role of the pineal gland. Biol Reprod 12: 216–220
Reiter RJ, Esquifino AI, Champney TH, Craft CM, Vaughan MK (1985) Pineal melatonin production in relation to sexual development in the male rat. In: Gupta D, Borrelli P, Attanasio A (eds) Paediatric neuroendocrinology. Croom & Helm, London, pp 190–202
Relkin R (1971) Relative efficacy of pinealectomy, hypothalamic and amygdaloid lesions in advancing puberty. Endocrinology 88: 415–418
Reppert SM (1982) Maternal melatonin: a source of melatonin for the immature mammal. In: Klein DC (ed) Melatonin rhythm generating system. Karger, Basel, pp 182–192
Rivest RW, Lang U, Aubert ML, Sizonenko PC (1985) Daily administration of melatonin delays rat vaginal opening and disrupts the first estrous cycles: evidence that these effects are synchronized by the onset of light. Endocrinology 116: 770–787
Waldhauser F, Wieszenbacher G, Zeithuber U, Waldhauser M, Frisch H, Wurtman RJ (1984) Fall in nocturnal serum melatonin levels during prepuberty and pubescence. Lancet 1: 362–365
Wurtman RJ, Axelrod J, Chu EW (1963) Melatonin, a pineal substance: effect on the rat ovary. Science 141: 277–278
Yuwiler A (1982) Sympathetic innervation of the pineal gland: effect of thyroxine and cortisol. In: Klein DC (ed) Melatonin rhythm generating system. Karger, Basel, pp 42–61
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Tang, P.L., Pang, S.F. The ontogeny of pineal and serum melatonin in male rats at mid-light and mid-dark. J. Neural Transmission 72, 43–53 (1988). https://doi.org/10.1007/BF01244631
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DOI: https://doi.org/10.1007/BF01244631