Summary
Repeated administrations of 7.5 mg/kg of pentazocine (for 14 days) resulted in a significant decrease in the affinity of3H-haloperidol binding to rat cortical sigma receptors without any changes in the maximal number of binding sites (Bmax). On the other hand, similar treatment with haloperidol (2 or 4 mg/kg) induced a dose dependent decrease in the Bmax values without affecting the affinity of the3H-haloperidol binding. These findings indicate that rat cortical sigma receptors are differentially regulated by pentazocine and haloperidol.
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Kizu, A., Yoshida, Y. & Miyagishi, T. Rat cortical sigma receptors differentially regulated by pentazocine and haloperidol. J. Neural Transmission 83, 149–153 (1991). https://doi.org/10.1007/BF01244461
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DOI: https://doi.org/10.1007/BF01244461