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Influence of relative response factor in the determination of organic microcontaminants with isotopically labeled standards

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Abstract

The use of isotopically labeled internal standards in the analysis of organic microcontaminants entails the determination of relative response factors (RRFs) of the unlabeled with respect to the labeled compounds. RRFs were measured daily during 28 replicate polychlorobiphenyl (PCB) analyses on two different sets of samples. Daily RRFs allowed more precise results to be attained than those provided by mean RRFs, the latter being the mean of all the daily RRFs obtained during the same series of analyses. Analytical applications to food matrices are presented, including the PCB contamination profile of an olive oil and that found in a matrix of Italian national mean diet. Based on the latter sample, also the polycyclic aromatic hydrocarbon (PAH) daily intake of Italians is assessed. Seven PAHs are determined.

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Authors and Affiliations

  1. Laboratory of Comparative Toxicology and Ecotoxicology, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161, Rome, Italy

    Luigi Turrio-Baldassarri, Alessandro di Domenico, Annarita Fulgenzi, Cinzia La Rocca, Nicola Iacovella, Fabrizio Rodriguez & Fabrizio Volpi

Authors
  1. Luigi Turrio-Baldassarri
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  2. Alessandro di Domenico
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  3. Annarita Fulgenzi
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  4. Cinzia La Rocca
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  5. Nicola Iacovella
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  6. Fabrizio Rodriguez
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  7. Fabrizio Volpi
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Turrio-Baldassarri, L., di Domenico, A., Fulgenzi, A. et al. Influence of relative response factor in the determination of organic microcontaminants with isotopically labeled standards. Mikrochim Acta 123, 45–53 (1996). https://doi.org/10.1007/BF01244377

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  • DOI: https://doi.org/10.1007/BF01244377

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