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Determination of acipimox in capsules by differential pulse polarography

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Abstract

A differential pulse polarographic (DPP) method has been developed for the determination of acipimox in its pharmaceutical formulations. Using Sörensen buffer pH 6.0 as supporting electrolyte a single, irreversible peak occurred at −0.79 V vs an Ag/AgCl reference electrode. The peak height vs concentration plot was found to be linear over the range of 10−6 to 6 × 10−4 mol/l. The detection limit is 60ng/ml. The analysis of a series of 10 Olbetam® 250 mg capsules showed an overall standard deviation of ± 4.18 mg and a Srel of ± 1.66%, respectively.

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Authors and Affiliations

  1. Institut für Pharmazeutische Chemie, Universität Graz, Schubertstrasse 1, A-8010, Graz, Austria

    Astrid Michelitsch, Petra Muhr, Manfred Schubert-Zsilavecz & Werner Likussar

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  1. Astrid Michelitsch
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  2. Petra Muhr
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  3. Manfred Schubert-Zsilavecz
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  4. Werner Likussar
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Michelitsch, A., Muhr, P., Schubert-Zsilavecz, M. et al. Determination of acipimox in capsules by differential pulse polarography. Mikrochim Acta 118, 147–152 (1995). https://doi.org/10.1007/BF01244354

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  • DOI: https://doi.org/10.1007/BF01244354

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