Summary
The effect was studied of a number of synthetic indoleamines, pteridines,β-carbolines, of AVT and of crude extracts from rat and ovine pineal glands on human melanoma cellsin vitro. The identified pineal substances as well as some of their analogues showed an inhibitory effect only at non-physiologically high concentrations. However, crude pineal extracts were more active than the synthetic pineal substances tested. They contain a compound which may have a tumor-inhibiting potency comparable to that of methotrexate but a different mechanism of action.
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Research scholars of the Society of Servants of God, New Delhi, India, working in the Cancer Research Programme of the Society.
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Bartsch, H., Bartsch, C., Noteborn, H.P.J.M. et al. Growth-inhibiting effect of crude pineal extracts on human melanoma cellsin vitro is different from that of known synthetic pineal substances. J. Neural Transmission 69, 299–311 (1987). https://doi.org/10.1007/BF01244350
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DOI: https://doi.org/10.1007/BF01244350