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Dopamine blockade of the thyroliberin-induced cyclic AMP accumulation in rat anterior pituitary

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Summary

Effects of dopamine and thyroliberin on the cyclic AMP concentration in the rat anterior pituitary gland were investigatedin vitro. Dopamine by itself had no effect on the anterior pituitary cAMP concentration but inhibited the cAMP-accumulating effect of thyroliberin.

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References

  • Arimura, A., Takahara, S., Davis, S., Nisbi, N., Schally, A. V. Catecholamines and the pituitary. In: Basic Applications and Clinical Uses of Hypothalamic Hormones (Charro Salgado, A. L., Fernandez-Durango, R., Lopez del Campo, J. G., eds.), pp. 200–210. New York: Excerpta Medica. 1976.

    Google Scholar 

  • Bowers, C. Y., Wu, B., Folkers, K. Mechanism involved in release of TSH and other pituitary hormones. In: Anatomical Neuroendocrinology (Stumpf, W. E., Grant, L. D., eds.), pp. 333–342. Basel: Karger. 1975.

    Google Scholar 

  • Cammanl, F., Massara, F., Belforte, L., Rosatello, A., Molinetti, G. M. Effect of dopamine on plasma growth hormone and prolactin levels in normal and acromegalic subjects. J. Clin. Endocr. Metab.44, 465–473 (1977).

    PubMed  Google Scholar 

  • Clement-Cormier, Y. C., Heindel, J. J., Robison, G. A. Adenylyl cyclase from a prolactin producing tumor cell: the effect of phenotiazines. Life Sci.21, 1357–1364 (1977).

    PubMed  Google Scholar 

  • Gilman, A. G. A protein binding assay for adenosine 3′ 5′-monophosphate. Proc. Natl. Acad. Sci. U. S. A.67, 305–312 (1970).

    PubMed  Google Scholar 

  • Guidottl, A., Naik, S. R., Kurosawa, A. Possible role of gamma-aminobudyric acid (GABA) in the regulation of cAMP system in rat anterior pituitary. Psychoneuroendocrinology2, 227–235 (1977).

    PubMed  Google Scholar 

  • Hill, M. K., Mac Lead, R. M., Orcutt, P. Dibutyryl cyclic AMP, adenosine and guanosine blockade of the dopamine, ergocryptine and apomorphine inhibition of prolactin releasein vitro. Endocrinology99, 1612–1617 (1976).

    PubMed  Google Scholar 

  • Irie, M., Tsushima, T. Increase of serum growth hormone concentration following thyrotropin releasing hormone injection in patients with acromegaly or gigantism. J. Clin. Endocr. Metab.35, 97–100 (1972).

    PubMed  Google Scholar 

  • Kebabian, J. W., Petzold, G. L., Greengard, P. Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain and its similarities to the dopamine receptors. Proc. Natl. Acad. Sci. U.S.A.69, 2145–2150 (1972).

    PubMed  Google Scholar 

  • Kimura, H., Calabro, M. A., MacLeod, R. M. Suppression of prolactin secretion and cAMP accumulation by dopamine in the pituitary. Fed. Proc.35, 305 (1976).

    Google Scholar 

  • Labrie, F., Borgeat, P., Lemay, A., Lemaire, S., Barden, N., Drovin, J., Lemaire, I., Jolicœur, P., Belanger, A. Role of cyclic AMP in the action of hypothalamic regulatory hormones. In: Advance in Cyclic Nucleotide Research (Drumond, G. I., Greengard, P., Robison, G. A., eds.), Vol. 5, pp. 787–801. New York: Raven Press. 1975.

    Google Scholar 

  • Liuzzi, A., Chiodini, P. G., Botalla, L., Gremascoli, G., Müller, E. E., Silvestrini, F. Decrease of plasma growth hormone levels in acromegalics following CB154 2-Br-alpha-ergocryptine administration. J. Clin. Endocr. Metab.38, 910–912 (1974).

    PubMed  Google Scholar 

  • Lloyd, H. M., Meares, J. D., Jacobi, J. Effects of oestrogen and bromocriptine onin vivo secretion and mitosis in prolactin cells. Nature255, 497–498 (1975).

    PubMed  Google Scholar 

  • MacLeod, R. M. Regulation of prolactin secretion. In: Frontiers in Neuroendocrinology (Martini, L., Ganong, W. F., eds.), pp. 169–194. New York: Raven Press. 1976.

    Google Scholar 

  • Maeda, K., Kato, Y., Chihara, K., Ohgo, S., Iwasaki, Y., Imura, H. Suppression by thyrotropin releasing hormone (TRH) of human growth hormone release induced by L-DOPA. J. Clin. Endocr. Metab.41, 408–411 (1975).

    PubMed  Google Scholar 

  • Nathanson, J. A. Cyclic nucleotides and nervous system function. Physiological Reviews57, 157–256 (1977).

    PubMed  Google Scholar 

  • Pawlikowski, M., Kunert-Radek, J. Investigations upon adenohypophysical cell proliferationin vitro: influence of oestradiol, thyrotropin releasing hormone, dibutyryl cyclic AMP and theophylline. Endocrinologia Experimentalis9, 135–140 (1975).

    PubMed  Google Scholar 

  • Pawlikowski, M., Kunert-Radek, J., Stępień, H.: Direct antiproliferative effect of dopamine agonists on the anterior pituitary gland in organ culture. J. Endocr. (in press, 1978).

  • Schmidt, M. J., Hill, L. E. Effects of ergots on adenylate cyclase activity in the corpus striatum and pituitary. Life Sci.20, 789–798 (1977).

    PubMed  Google Scholar 

  • Stępień, H., Wolaniuk, A., Pawlikowski, M. Effects of pimozide and bromocriptine on anterior pituitary cell proliferation. J. Neural Transm.42, 239–244 (1978).

    PubMed  Google Scholar 

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Author notes

  1. M. Pawlikowski

    Present address: Department of Experimental Endocrinology, Institute of Endocrinology, Medical Academy, Lodz, Poland

Authors and Affiliations

  1. Department of Experimental Endocrinology, Institute of Endocrinology, Medical Academy, Lodz, Poland

    E. Karasek, J. Kunert-Radek & H. Stępień

Authors
  1. M. Pawlikowski
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  2. E. Karasek
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  3. J. Kunert-Radek
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  4. H. Stępień
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Additional information

This paper was supported by the Polish Academy of Sciences, Grant No. 10.4.2.01.5.5.

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Pawlikowski, M., Karasek, E., Kunert-Radek, J. et al. Dopamine blockade of the thyroliberin-induced cyclic AMP accumulation in rat anterior pituitary. J. Neural Transmission 45, 75–79 (1979). https://doi.org/10.1007/BF01243882

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  • DOI: https://doi.org/10.1007/BF01243882

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