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Circadian course of body temperature and the excretion of MHPG and VMA in a patient with bipolar depression

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Summary

A 38-year old woman with a bipolar affective disorder was examined for 10 days during a serious retarded depression phase and for 10 days during the subsequent symptom-free interval. During depression the MHPG-excretion showed a significantly shorter circadian periodicity of 20.5 hours, whereas the periodicity of body temperature and VMA amounted to 24 hours. During the symptom-free interval the circadian periodicity of all parameters was 24 hours. These results indicate that the depression phase of a bipolar affective disorder in this patient is related to a desynchronization of central NA function with peripheral NA activity and body temperature.

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References

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Author notes

  1. B. Pflug

    Present address: University Psychiatric Hospital and Institute of Biology, University of Tübingen, Germany

Authors and Affiliations

  1. University Psychiatric Hospital and Institute of Biology, University of Tübingen, Germany

    W. Engelmann & H. -J. Gaertner

Authors
  1. B. Pflug
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  2. W. Engelmann
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  3. H. -J. Gaertner
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Supported by Deutsche Forschungsgemeinschaft PF 142/3.

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Pflug, B., Engelmann, W. & Gaertner, H.J. Circadian course of body temperature and the excretion of MHPG and VMA in a patient with bipolar depression. J. Neural Transmission 53, 213–215 (1982). https://doi.org/10.1007/BF01243412

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  • DOI: https://doi.org/10.1007/BF01243412

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