Skip to main content
SpringerLink
Log in

Dissociated effects of apomorphine on various nociceptive responses in mice

  • Original Papers
  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary

The effects of increasing doses of apomorphine were studied in mice in six nociceptive tests: (1) withdrawal of the tail immersed in hot water, (2) vocalization induced by the electrical stimulation of the tail, (3) tail flick using a radiant beam, (4) withdrawal of a tail-clip, (5) writhing induced by the i.p. injection of phenylbenzoquinone, (6) forepaw licking and jump latencies on a hot plate. Only in the tests (5) and (6), an apparent analgesia was obtained. Differences were observed between tests (5) and (6), as to: (i) the apparent relative effectiveness of (−)sulpiride (more effective in test [5] than in test [6]), (ii) the naloxone-induced modifications of apomorphine effects (whereas naloxone antagonized apomorphine effects in test [6], it did not in test [5]), (iii) the decrease of apomorphine-induced responses by prevention of hypothermia (in test [6] but not in test [5]). These data suggest that APO-induced increased jump latencies are at least partly related with hypothermia and endogenous opioid systems, whereas APO effect on the writhing test depends on the stimulation of dopamine receptors particularly sensitive to sulpiride and is independant from body temperature and opioidergic transmissions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Andén NE, Rubenson A, Fuxe K, Hökfelt T (1967) Evidence for dopamine receptor stimulation by apomorphine. J Pharm Pharmacol 19: 627–629

    Google Scholar 

  • Appelbaum BD, Holtzman, SG (1984) Characterization of stress-induced potentiation of opioid effects in the rat. J Pharmacol Exp Ther 231: 555–565

    Google Scholar 

  • Ben-Sreti MM, Gonzales JP, Sewell RD (1983) Differential effects of SKF 38393 and LY 141865 on nociception and morphine analgesia. Life Sci [Suppll] 33: 665–668

    Google Scholar 

  • Bodnar RJ, Glusman M, Brutus M, Spiaggia A, Kelly DD (1979) Analgesia induced by cold-water stress: attenuation following hypophysectomy. Physiol Behav 23: 53–62

    Google Scholar 

  • Burt D, Enna S, Creese I, Snyder S (1975) Dopamine receptor binding in the corpus striatum of mammalian brain. Proc Natl Acad Sci USA 72: 4655–4659

    Google Scholar 

  • Costall B, Fortune DH, Naylor RB (1979) Neuropharmacological studies on the neuroleptic potential of domperidone (R 33812). J Pharm Pharmacol 31: 344–351

    Google Scholar 

  • Costentin J, Vlaiculescu A, Chaillet P, Ben Natan L, Aveaux D, Schwartz JC (1986) Dissociated effects of inhibitors of enkephalin-metabolizing peptidases or naloxone on various nociceptive responses. Eur J Pharmacol 123: 37–44

    Google Scholar 

  • Czlonkowski A, Hollt V, Herz A (1978) Binding of opiates and endogenous opioid peptides to neuroleptic receptor sites in the corpus striatum. Life Sci 22: 953–959

    Google Scholar 

  • D'Amour FE, Smith DL (1941) A method for determining loss of pain sensation. J Pharmacol Exp Ther 72: 74–77

    Google Scholar 

  • Dennis SG, Melzack R, Gutman S, Boucher F (1980) Pain modulation by adrenergic agents and morphine as measured by three pain tests. Life Sci 26: 1247–1255

    Google Scholar 

  • Dunai-Kovacs S, Szekely JI (1977) Effect of apomorphine on the antinociceptive activity of morphine. Psychopharmacology 53: 65–72

    Google Scholar 

  • Eddy WB, Leimbach D (1953) Synthetic analgesics (II): dithenylbutenyl and dithenylbutylamines. J Pharmacol Exp Ther 107: 385–389

    Google Scholar 

  • Ernst A (1967) Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats. Psychopharmacologia (Berlin) 10: 316–323

    Google Scholar 

  • Gonzales JP, Sewell RD, Spencer PS (1981) Evidence for central selective dopamine receptor stimulation in the mediation of nomifensine-induced hyperalgesia and the effects of opiate antagonists. Neuropharmacology 20: 1039–1045

    Google Scholar 

  • Görlitz BD, Frey HH (1972) Central monoamines and antinociceptive drug action. Eur J Pharmacol 20: 171–180

    Google Scholar 

  • Haffner F (1929) Experimentelle Prüfung schmerzstillender Mittel. Deut Med Wochenschr 55: 731–737

    Google Scholar 

  • Hill RG (1981) The status of naloxone in the identification of pain control mechanisms operated by endogenous opioids. Neurosci Lett 21: 217–222

    Google Scholar 

  • Janssen PAJ, Niemegeers CJE, Schellekens KHL, Lenaerts FM (1967) Is it possible to predict the clinical effects of neuroleptic drugs (major transquillizers) from animal data? Arzneim-Forsch (Drug Res) 17: 841–854

    Google Scholar 

  • Jensen TS, Schroder HD, Smith DF (1984) The role of spinal pathways in dopamine mediated alteration in the tail flick reflex in rats. Neuropharmacology 23: 149–153

    Google Scholar 

  • Jensen TS, Smith DF (1982) Dopaminergic effects on tail-flick response in spinal rats. Eur J Pharmacol 79: 129–133

    Google Scholar 

  • Jensen TS, Yaksh TL (1984) Effects of an intrathecal agonist, apomorphine, on thermal and chemical evoked noxious responses in rats. Brain Res 296: 285–293

    Google Scholar 

  • Laduron PM, Leysen JE (1979) Domperidone, a specificin vitro dopamine antagonist, devoid ofin vivo central dopaminergic activity. Biochem Pharmacol 28: 2161–2169

    Google Scholar 

  • Leysen J, Tollenaere J, Koch M, Laduron P (1977) Differentiation of opiate and neuroleptic receptor binding in rat brain. EurJ Pharmacol 43: 253–261

    Google Scholar 

  • Litchfield JTJr, Wilcoxon F (1949) A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 96: 99–115

    Google Scholar 

  • Lin MT, Wu JJ, Chandra A, Tsay BL (1981) Activation of striatal dopamine receptors induces pain inhibition in rats. J Neural Transm 51: 213–222

    Google Scholar 

  • Miley DP, Abrams AA, Atkinson TH, Janowsky DS (1978) Successful treatment of thalamic pain with apomorphine. Am J Psychiat 135: 1230–1237

    Google Scholar 

  • Moon BH, Feigenbaum JJ, Carson PE, Klawans HL (1980) The role of dopaminergic mechanisms in naloxone-induced inhibition of apomorphine-induced stereotyped behaviour. EurJ Pharmacol 61: 71–78

    Google Scholar 

  • Nilsen PL (1961) Studies on algesimetry by electrical stimulation of the mouse tail. Acta Pharmacol (Copenh) 18: 10–17

    Google Scholar 

  • O'Connor SE, Brown RA (1982) The pharmacology of sulpiride, a dopamine receptor antagonist. Gen Pharmacol 13: 185–195

    Google Scholar 

  • Ohman R, Larsson M, Nilsson IM, Engel J, Carlsson A (1977) Neurometabolic and behavioral effects of haloperidol in relation to drug levels in serum and brain. Naunyn-Schmiedebergs' Arch Pharmacol 299: 105–114

    Google Scholar 

  • Paalzow GH, Paalzow LK (1983) Opposing effects of apomorphine on pain in rats. Evaluation of the dose-response curve. Eur J Pharmacol 88: 27–39

    Google Scholar 

  • Protais P, Bonnet JJ, Costentin J (1983) Pharmacological characterization of the receptors involved in the apomorphine-induced polyphasic modifications of locomotor activity in mice. Psychopharmacology 81: 126–134

    Google Scholar 

  • Puech AJ, Simon P, Chermat R, Boissier JR (1974) Profil neuropsychopharmacologique de l'apomorphine. J Pharmacol (Paris) 2: 241–254

    Google Scholar 

  • Quock RM, Lucas TS (1981) Enhancement of apomorphine-induced climbing in mice by reversible and irreversible narcotic antagonist drugs. Life Sci 28: 1421–1424

    Google Scholar 

  • Quock RM, Lucas TS, Hartl TJ (1981) Potentiation of apomorphine-induced stereotypies by naloxone and irreversible narcotic antagonist drugs. Life Sci 28: 1421–1424

    Google Scholar 

  • Robertson T, Weston R, Lewis MJ, Barasi S (1981) Evidence for the potentiation of the antinociceptive action of morphine by bromocriptine. Neuropharmacology 20: 1029–1032

    Google Scholar 

  • Sigmund E, Cadmus R, Lu G (1957) Method for evaluating both non narcotic and narcotic analgesics. Proc Soc Exp Biol Med 95: 729–735

    Google Scholar 

  • Sewell RDE, Spencer PSJ (1975) Antinociceptive activity of narcotic agonists and partial agonists in mice given biogenic amines by intracerebroventricular injection. Psychopharmacologia (Berl) 42: 67–75

    Google Scholar 

  • Spiaggia A, Bodnar RJ, Kelly DD, Glusman M (1979) Opiate and non-opiate mechanisms of stress-induced analgesia: cross tolerance between Stressors. Pharmacol Biochem Behav 10: 761–765

    Google Scholar 

  • Tocco DR, Maickel RP (1984) Analgesic activities of amphetamine isomers. Arch Int Pharmacodyn 268: 25–31

    Google Scholar 

  • Tricklebank MD, Hutson PH, Curzon G (1984) Involvement of dopamine in the antinociceptive response to footshock. Psychopharmacology 82: 185–188

    Google Scholar 

  • Tulunay FC, Sparber SB, Takemori AE (1983) The effect of dopaminergic stimulation and blockade on the nociceptive and antinociceptive responses of mice. Eur J Pharmacol 33: 65–70

    Google Scholar 

  • Zetler G (1983) Apomorphine separates the antinociceptive effects of cholecystokinin octapeptide and ceruletide from those of morphine. Eur J Pharmacol 92: 151–154

    Google Scholar 

Download references

Author information

Author notes

  1. J. Costentin

    Present address: Laboratoire de Pharmacodynamie et Physiologie U.E.R. de Médecine et de Pharmacie de Rouen, U.A. 1170 du C.N.R.S., Saint Etienne du Rouvray, France

Authors and Affiliations

  1. Laboratoire de Pharmacodynamie et Physiologie U.E.R. de Médecine et de Pharmacie de Rouen, U.A. 1170 du C.N.R.S., Saint Etienne du Rouvray, France

    F. Gonzales-Rios, Adina Vlaiculescu, L. Ben Natan & P. Protais

Authors
  1. F. Gonzales-Rios
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Adina Vlaiculescu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Ben Natan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Protais
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. Costentin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gonzales-Rios, F., Vlaiculescu, A., Ben Natan, L. et al. Dissociated effects of apomorphine on various nociceptive responses in mice. J. Neural Transmission 67, 87–103 (1986). https://doi.org/10.1007/BF01243362

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01243362

Key words

Search

Navigation