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über die antivirale Wirkung einiger Imidazolderivate

Antiviral activity of imidazole derivatives. IV. Sensitivity of different viruses IV. Mitteilung: Die Empfindlichkeit verschiedener Viren

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Zusammenfassung

Die in einem Screeningprogramm geprüften und wegen ihrer guten antiviralen Wirkung gegen Mengovirus ausgewÄhlten Imidazolderivate BC 16, 59, 60 und 63 zeigten keine Hemmung gegenüber Schafabort-, Vaccinia-, Pseudorabies-, Sindbis-, Newcastle disease-und Geflügelpestvirus, wohl aber gegenüber ECHO-Virus Typ 11, 30 und 33. Eine mÄ\ige Hemmwirkung konnte auch gegen Poliovirus Typ 2, die attenuierten Polio-ImpfstÄmme Typ 2 und 3 sowie gegen Coxsackie-virus B 2 und B 4 nachgewiesen werden. Poliovirus Typ 1 und 3, der attenuierte Polio-Stamm Typ 1 sowie Coxsackievirus B 3 und B 5 wurden am wenigsten beeinflu\t.

Summary

The imidazole derivatives BC 16, 59, 60, and 63 which had been selected by a screening program because of their particularly antiviral activity against mengo-virus, were also shown to be effective against a number of enteroviruses. Their sensitivity was found decreasing in the order ECHO virus types 11, 30 and 33, poliovirus type 2, live polio vaccine strains types 2 and 3, Coxsackie virus B 2 and B 4, poliovirus types 1 and 3, the polio vaccine strain 1, and Coxsackie virus B 1, B 3 and B 5. There was no evidence for activity against sheep abortion, vaccinia, pseudorabies, sindbis, Newcastle disease and fowl plague virus. The inhibitory spectrum of the imidazoles under question resembles that of benzimidazole derivatives. With respect to the virological results obtained as yet the imidazoles are considered of being selective inhibitors of picornaviruses.

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Literatur

  1. Tonew, M., undE. M. Tonew: über die antivirale Wirkung einiger Imidazol-derivate. 1. Die Hemmung der Vermehrung des Mengovirus in FL-Zellen. Arch. ges. Virusforsch.33, 319–329 (1971).

    Google Scholar 

  2. Tonew, M., undS. Bleecken: über die antivirale Wirkung einiger Imidazol-derivate. 2. Untersuchungen zur ENS und Proteinsynthese. Arch. ges. Virusforsch.33, 330–337 (1971).

    Google Scholar 

  3. Tonew, E. M., M. Tonew undG. Strohbach: über die antivirale Wirkung einiger Imidazolderivate. 3. Autoradiographische Untersuchungen zur Einwirkung von 1-Butyl-4-(4,-allyloxyphenyl)-imidazolhydrochlorid auf die RNS-Synthese in FL-Zellen nach Mengovirusinfektion. Arch. ges. Virusforsch.34, 244–249 (1971).

    Google Scholar 

  4. Tonew, E., undM. Tonew: Die Wirkung von Cycloheximid auf Abortusvirus der Schafe, Sindbis-Virus und andere Viren in Screening-Untersuchungen. Zbl. Bakt. I. Abt. Orig.211, 437–444 (1969).

    Google Scholar 

  5. Tonew, E., K. Eckardt, W. Fleck undP. Zöpel: Die antivirale Wirkung des Streptomyceten-Antibioticums IMET A 8136/A (Borrelidin) auf das Virus der klassischen Geflügelpest. Z. allg. Mikrobiol.10, 353–361 (1970).

    Google Scholar 

  6. Wallis, Cr., Fr. Morales, J. Powell, andJ. L. Melnick: Plaque enhancement of enteroviruses by magnesium chloride, cysteine and pankreatin. J. Bact.91, 1932–1935 (1966).

    Google Scholar 

  7. Liebhaber, H., andK. K. Takemoto: Alteration of plaque morphology of EMC virus with polycations. Virology14, 502–504 (1961).

    Google Scholar 

  8. Choppin, P. W., andH. J. Eggers: Heterogeneity of Coxsackie B4 virus: two kinds of particles which differ in antibody sensitivity, growth rate, and plaque size. Virology18, 470–476 (1962).

    Google Scholar 

  9. Dianzani, F., A. Quercioli, L. Del Granden Quercioli, andS. Gagnoni: Influence of DEAE-dextran on plaque production by Semliki forest virus. Acta virol.12, 275–276 (1968).

    Google Scholar 

  10. Bornowski, H.: Dissertation, Berlin. 1969.

  11. Eggers, H. J., andI. Tamm: Selektive Hemmung der Vermehrung von Entero-viren durch das 2-(α-Oxy-benzyl)-benzimidazol. Z. Hyg. Infekt.-Kr.147, 588–594 (1961).

    Google Scholar 

  12. O'Sullivan, D. G.: New 1,2-disubstituted benzimidazoles with high inhibition effects on polio virus replication. Experientia23, 704–706 (1967).

    Google Scholar 

  13. Eggers, H., J., andI. Tamm: Spectrum and characteristics of the virus inhibitory action of 2-(α-hydroxybenzyl)-benzimidazole. J. exp. Med.113, 657–682 (1961).

    Google Scholar 

  14. Tamm, I., andH. J. Eggers: Differences in the selective virus inhibitory action of 2-(α-hydroxybenzyl)-benzimidazole and guanidin-HCl. Virology18, 439–447 (1962).

    Google Scholar 

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Author notes

  1. M. Tonew

    Present address: Zentralinstitut für Mikrobiologie und Experimentelle Therapie der Deutschen Akademie der Wissenschaften zu Berlin, Jena, DDR

Authors and Affiliations

  1. Zentralinstitut für Mikrobiologie und Experimentelle Therapie der Deutschen Akademie der Wissenschaften zu Berlin, Jena, DDR

    E. M. Tonew & P. Zöpel

  2. Bereich Experimentelle Therapie, Deutschland

    M. Tonew, E. M. Tonew & P. Zöpel

Authors
  1. M. Tonew
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  2. E. M. Tonew
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  3. P. Zöpel
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Tonew, M., Tonew, E.M. & Zöpel, P. über die antivirale Wirkung einiger Imidazolderivate. Archiv f Virusforschung 34, 250–254 (1971). https://doi.org/10.1007/BF01242999

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  • DOI: https://doi.org/10.1007/BF01242999

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