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Infectious influenza virus-antibody complex

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Summary

Neutralization of infectivity of influenza virus appears to depend on the quantitative relationship between the virus and the antibody in the mixture. In subneutralized infectious virus-antiserum mixture, the virus may exist in infectious virus-antibody complex, the presence of which can be revealed by the addition of specific antiglobulin. The antiglobulin molecules by attaching to the antibody of sensitized virus, bring about aggregation of sensitized virions which results in the reduction of a number of infectious units in the mixture. The possible practical significance of these observations is discussed.

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Author notes

  1. E. Zalan

    Present address: Virus Laboratory, Public Health Laboratories, Ontario Department of Health, Toronto, Ontario, Canada

Authors and Affiliations

  1. Virus Laboratory, Public Health Laboratories, Ontario Department of Health, Toronto, Ontario, Canada

    E. Borman & N. A. Labzoffsky

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  1. E. Zalan
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  2. E. Borman
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  3. N. A. Labzoffsky
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Zalan, E., Borman, E. & Labzoffsky, N.A. Infectious influenza virus-antibody complex. Archiv f Virusforschung 34, 209–213 (1971). https://doi.org/10.1007/BF01242994

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  • DOI: https://doi.org/10.1007/BF01242994

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