Summary
A characteristic purple-coloured hemorrhage was produced in rabbits at the site of an intradermal injection of 100 Μg of epinephrine when herpes simplex virus had been injected on the same site 3–4 hours previously or when an intravenous injection of vesicular stomatitis virus had been given 4 hours previously. Both of these viruses had a pyrogenic effect 2–4 hours after intravenous injection in rabbits. Rabbits given an intravenous injection of vesicular stomatitis virus showed resistance to the pyrogenic effect of a second intravenous injection of this virus given 24 hours later, but showed no such resistance to an injection of herpes simplex virus. Rabbits which were thus resistant to the pyrogenic effect of vesicular stomatitis virus were also resistant to the above described skin lesions produced at the site of intradermal injections of epinephrine.
The epinephrine induced skin lesions were prevented by neutralization of these viruses with specific antisera and could also be inhibited by the intravenous injection of dibenzyline 30 minutes before the intradermal injection of epinephrine.
The injection of epinephrine potentiated the lethality of rabbits after intravenous injection of a large dose of herpes simplex virus.
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This investigation was supported by grants from the National Eye Institute (E Y 00072), Bethesda, Maryland, the National Society for Prevention of Blindness, Inc. and Fight for Sight, Inc. (G-420), both in New York, New York, U.S.A.
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Tokumaru, T. Production of epinephrine-induced skin lesions and fever following local and systemic injections of herpes simplex and vesicular stomatitis viruses in the rabbit. Archiv f Virusforschung 34, 179–188 (1971). https://doi.org/10.1007/BF01242991
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DOI: https://doi.org/10.1007/BF01242991