Summary
Organ cultures were inoculated with viruses belonging to five different morphological groups. Cells and debris were abraded from the cultures four days later and examined by a negative contrast technique. All but the smallest particles were readily recognised. This method has been of value in visualising some recently isolated viruses.
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Tyrrell, D.A.J., Almeida, J.D. Direct electron-microscopy of organ cultures for the detection and characterization of viruses. Archiv f Virusforschung 22, 417–425 (1967). https://doi.org/10.1007/BF01242962
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DOI: https://doi.org/10.1007/BF01242962