Skip to main content
SpringerLink
Log in

Experimental infection with Sendai virus in mice

  • Published:
Archiv für die gesamte Virusforschung Aims and scope Submit manuscript

Summary

Less than one plaque-forming unit (PFU) of Sendai virus was required to produce a serologically demonstrable infection when inoculated intranasally into mice of a specific pathogen-free colony showing no evidence of previous infection. No difference in susceptibility to serologically demonstrable infection and fatal disease was observed between male and female mice or between 4-week-old and 12-week-old mice.

The distribution of virus and the antibody response were studied in 4-week-old and 12-week-old mice inoculated with 50 PFU of Sendai virus. Virus was recovered from the lungs and nasal washings from 24 hours after inoculation to at least 10 days later. Virus titers reached maximum levels at 4 to 6 days. No virus was recovered from the blood, intestines, kidneys and urine. Complement-fixing (CF), hemagglutination-inhibiting (HI) and neutralizing antibodies were demonstrable from the 8th day. Neutralizing antibody persisted at a higher level than did CF and HI antibodies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Cook, M. K., andR. M. Chanock: Amer. J. Hyg.77, 150 (1963).

    Google Scholar 

  • Craighead, J. E.: Brit. J. exp. Path.47, 235 (1966).

    Google Scholar 

  • Fukumi, H., H. Mizutani, Y. Takeuchi, Y. Tajima, K. Imaizumi, T. Tanaka, andJ. Kaneko: Jap. J. med. Sci. Biol.15, 153 (1962).

    Google Scholar 

  • Fukumi, H., F. Nishikawa, andT. Kitayama: Jap. J. med. Sci. Biol.7, 345 (1954).

    Google Scholar 

  • Hayashi, S.: Virus (Tokyo)11, 108 (1961).

    Google Scholar 

  • Maksimovich, N. A., andKhou-Yun-De: Vop. Virus.2, 168 (1962).

    Google Scholar 

  • Nagata, I., K. Maeno, S. Yoshii, andT. Matsumoto: Arch. ges. Virusforsch.15, 257 (1965).

    Google Scholar 

  • Nakamura, K.: Biken J.8, 155 (1965).

    Google Scholar 

  • Parker, J. C., R. W. Tennant, T. G. Ward, andW. P. Rowe: Science146, 936 (1964).

    Google Scholar 

  • Parker, J. C., R. W. Tennant, T. G. Ward, andW. P. Rowe: J. nat. Cancer Inst.34, 371 (1965).

    Google Scholar 

  • Reed, L. J., andH. Muench: Amer. J. Hyg.27, 493 (1938).

    Google Scholar 

  • Sawicki, L.: Nature (Lond.)192, 1258 (1961).

    Google Scholar 

  • Sawicki, L.: Acta virol.6, 347 (1962).

    Google Scholar 

  • Schulman, J. L., andE. D. Kilbourne: J. exp. Med.118, 267 (1963).

    Google Scholar 

  • Sever, J. L.: J. Immunol.88, 320 (1962).

    Google Scholar 

  • Shigeta, S.: Tohoku J. exp. Med.83, 114 (1964).

    Google Scholar 

  • Tennant, R. W., J. C. Parker, andT. G. Ward: Viruses of laboratory rodents (Ed.:R. Holdenried), Nat. Cancer Inst. Monograph20, 93 (1966).

Download references

Author information

Author notes

  1. M. C. J. van Nunen

    Present address: Department of Hygiene, University of Nijmegen, The Netherlands

Authors and Affiliations

  1. Department of Hygiene, University of Nijmegen, The Netherlands

    J. van der Veen

Authors
  1. M. C. J. van Nunen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. van der Veen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

van Nunen, M.C.J., van der Veen, J. Experimental infection with Sendai virus in mice. Archiv f Virusforschung 22, 388–397 (1967). https://doi.org/10.1007/BF01242959

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01242959

Keywords

Search

Navigation