Summary
The relationships of the γM, 7Sγ1 and 7Sγ2 immunoglobulins to the pathogenesis of herpetic skin infections and encephalitis were investigated in guinea pigs. The differences in the sequential appearance, avidity and secondary response of these immunoglobulins to booster inoculations of viral antigen and the types of imnmnological tissue injuries in immunized animals were detected. When the immunoglobulins were purified by chromatographic and electrophoretic techniques there was a 3-fold difference between the passive protective potencies of the 7 Sγ1 and 7 Sγ2 immunoglobulins. However, these immunoglobulins could protect guinea pigs only when they were given prior to the phase of exponential multiplication of the virus.
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This investigation was supported by research grant (AI-05612) from National Institute of Allergy and Infectious Diseases, U.S. Public Health Service, Bethesda, Maryland, U.S.A.
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Tokumaru, T. The protective effect of different immunoglobulins against herpetic encephalitis and skin infection in guinea pigs. Archiv f Virusforschung 22, 332–348 (1967). https://doi.org/10.1007/BF01242954
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DOI: https://doi.org/10.1007/BF01242954