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Inhibition of brain protein synthesis by doses of L-DOPA that disaggregate brain polyribosomes

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Summary

Rats receiving doses of L-DOPA sufficient to cause disaggregation of brain polyribosome profiles exhibitin vivo inhibition of uptake of14C-leucine or14C-lysine into brain protein coincident with the disaggregation.

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References

  • Aoki, K., andF. L. Siegel: Hyperphenylalaninemia: Disaggregation of brain polyribosomes in young rats. Science168, 129–130 (1970).

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  • Hartmann, J. F., andR. A. Becker: Ultrastructural evidence against in vivo disaggregation of brain polyribosomes after administration of L-dopa or phenylalanine. J. Neural Trans.34, 73–77 (1973).

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  • Weiss, B. F., H. N. Munro, andR. J. Wurtman: L-dopa: Disaggregation of brain polysomes and elevation of brain tryptophan. Science173, 833 to 835 (1971).

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Author notes

  1. R. J. Wurtman

    Present address: Department of Nutrition and Food Science, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA

Authors and Affiliations

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    1. H. N. Munro
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    2. L. Roel
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    3. R. J. Wurtman
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    Munro, H.N., Roel, L. & Wurtman, R.J. Inhibition of brain protein synthesis by doses of L-DOPA that disaggregate brain polyribosomes. J. Neural Transmission 34, 321–323 (1973). https://doi.org/10.1007/BF01242753

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    • DOI: https://doi.org/10.1007/BF01242753

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