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Induction of interferon in L cells by polyinosinic-polycytidylic acid in the presence of cationic compounds

II. Basic dyes

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Summary

Four basic dyes, two thiazine dyes (toluidine blue, methylene blue) and two acridine dyes (trypaflavine, acridine orange), enhance the induction of interferon by polyIC in L cells. This effect is more likely the result of charge neutralization than protection of the polynucleotide against degradation by RNase.

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Abbreviations

poly(I) · poly(C):

poly IC

poly(I-3H) · poly(C):

3H-poly IC

diethylaminoethyl dextran:

DEAE-dextran

inosinic acid:

IMP

References

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  2. Lodemann, E., and J.Diederich: Unpublished results.

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  4. Popa, L. M., andR. Repanovici: The study of toluidine blue-ribosomal RNA complexes. Biochim. biophys. Acta (Amst.)182, 158–168 (1969).

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  5. Semmel, M., andM. Daune: Etudes des complexes de colorantes basiques avec le RNA. Biochim. biophys. Acta (Amst.)145, 561–576 (1967).

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  6. Wacker, A., E. Lodemann, J. Diederich, K. Mohrbutter, and U.Lauschke: Induction of interferon in L cells by polyinosinic-polycytidylic acid in the presence of cationic compounds. I. Polycations. Arch. ges. Virusforsch.36, 71–79 (1972).

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Author notes

  1. A. Wacker

    Present address: Institute of Therapeutical Biochemistry, University of Frankfurt (Main), Federal Republic of Germany

Authors and Affiliations

  1. Institute of Therapeutical Biochemistry, University of Frankfurt (Main), Federal Republic of Germany

    E. Lodemann, J. Diederich & U. Sattler

Authors
  1. E. Lodemann
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  2. J. Diederich
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  3. U. Sattler
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  4. A. Wacker
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Lodemann, E., Diederich, J., Sattler, U. et al. Induction of interferon in L cells by polyinosinic-polycytidylic acid in the presence of cationic compounds. Archiv f Virusforschung 40, 87–92 (1973). https://doi.org/10.1007/BF01242640

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  • DOI: https://doi.org/10.1007/BF01242640

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