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Basic dyes as inducers of interferon-like activity in mice

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Summary

Four basic dyes, toluidine blue, methyleneblue, trypaflavine and acridine orange promote the appearance of an antiviral activity in the serum of mice after intraperitoneal injection of one of the compounds. Optimal activity was determined 4–10 hours after injection of a dose of 50–70 μg trypaflavine per mouse. Preliminary characterization experiments suggest the antiviral activity to be interf eron or an interferon-like substance.

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Author notes

  1. A. Wacker

    Present address: Institute of Therapeutical Biochemistry, University of Frankfurt (Main), Federal Republic of Germany

Authors and Affiliations

  1. Institute of Therapeutical Biochemistry, University of Frankfurt (Main), Federal Republic of Germany

    J. Diederich & E. Lodemann

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  1. J. Diederich
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  2. E. Lodemann
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  3. A. Wacker
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Diederich, J., Lodemann, E. & Wacker, A. Basic dyes as inducers of interferon-like activity in mice. Archiv f Virusforschung 40, 82–86 (1973). https://doi.org/10.1007/BF01242639

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  • DOI: https://doi.org/10.1007/BF01242639

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