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Persistent Borna virus infection in adult hamsters

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Summary

Adult Syrian hamsters (Mesocricetus auratus) were inoculated intracerebrally with Borna virus. Neither clinical nor pathological evidence of Borna encephalitis developed in any of the animals for an observation time of up to 309 days post inoculation. Sera from inoculated hamsters did not show complement fixing activity during this time. The brains, however, after a variably long incubation time, contained complement fixing Borna antigen and induced Borna encephalitis when injected into the rabbit.

A persistent infection state was obtained in adult hamsters inoculated intracerebrally with Borna virus. The persistent form of the Borna infection in the hamsters sheds some new light on certain aspects of Borna disease. In addition, this model may be useful to the study of persistent infections and possibly slow virus diseases.

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Author notes

  1. A. P. Anzil & K. Blinzinger

    Present address: Neuropathological Division, Theoretical Institute of the Max Planck Institute for Psychiatry, Munich

  2. A. Mayr

    Present address: Institute for Microbiology and Infectious Diseases of Animals of the Ludwig Maximilian University, Munich, Federal Republic of Germany

Authors and Affiliations

  1. Neuropathological Division, Theoretical Institute of the Max Planck Institute for Psychiatry, Munich

    A. Mayr

  2. Institute for Microbiology and Infectious Diseases of Animals of the Ludwig Maximilian University, Munich, Federal Republic of Germany

    A. P. Anzil & K. Blinzinger

Authors
  1. A. P. Anzil
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  2. K. Blinzinger
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  3. A. Mayr
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Anzil, A.P., Blinzinger, K. & Mayr, A. Persistent Borna virus infection in adult hamsters. Archiv f Virusforschung 40, 52–57 (1973). https://doi.org/10.1007/BF01242635

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  • DOI: https://doi.org/10.1007/BF01242635

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