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Different histopathological response to Arenovirus infection in thymectomized mice

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Summary

In this paper the survival and the histopathology of normal and thymectomized mice infected with some Arenoviruses is reported.

Normal newborn mice infected intracerebrally with Junín, Machupo, Tacaribe and Amaparí virus showed similar histopathological changes in the central nervous system characterized by choroiditis, glial hyperplasia, vasculitis and perivasculitis with infiltration of lymphocytic cells.

In thymectomized mice infected with Junín, Machupo and Tacaribe virus, there was no evidence of disease, survival reached almost 100% and no pathological alterations were observed in the brain.

In contrast, thymectomized mice infected with Amaparí virus showed the same percentage of mortality and similar histopathological changes as non-thymectomized animals.

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Author notes

  1. Santiago C. Besuschio

    Present address: Department of Microbiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina

Authors and Affiliations

  1. Department of Microbiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina

    Mercedes C. Weissenbacher & Gabriel A. Schmuñis

Authors
  1. Santiago C. Besuschio
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  2. Mercedes C. Weissenbacher
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  3. Gabriel A. Schmuñis
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Additional information

This research was supported by Grant N∘ 4908/71 from “Consejo National de Investigaciones Cientificas y Técnicas”, República Argentina, and by funds from “Comisión Coordinadora para el estudio y lucha contra la Fiebre Hemorrágica Argentina” de la Subseeretaría de Salud Pública, República Argentina.

Chairman Department of Pathology, National Academy of Medicine, República Argentina.

Members of Research Career from the “Consejo Nacional de Investigaciones Cientificas y Técnicas”, República Argentina.

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Besuschio, S.C., Weissenbacher, M.C. & Schmuñis, G.A. Different histopathological response to Arenovirus infection in thymectomized mice. Archiv f Virusforschung 40, 21–28 (1973). https://doi.org/10.1007/BF01242632

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  • DOI: https://doi.org/10.1007/BF01242632

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