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Biological activity of 2-phenylethanol and its derivatives

VIII. Influence on herpesvirus DNA-synthesis in rabbit kidney cells

Summary

The biosynthesis of herpesvirus DNA in rabbit kidney cells is inhibited to 50% by PEA (2-Phenylethanol) at 0.65 mg PEA/ml. The inhibition of cellular DNA synthesis in uninfected cells by PEA is about twice as sensitive as that of viral DNA synthesis.

The cellular DNA-dependent DNA polymerase is inhibited in a non-competitive way. The 50% inhibitory concentration amounts to 0.8 mg PEA/ml.

In contrast the herpesvirus induced DNA-dependent DNA polymerase is 10-fold more resistant towards PEA.

It is assumed that, contrary to the synthesis of cellular DNA, the PEA induced inhibition of viral DNA synthesis is not caused by an inhibition of the virus-induced DNA-dependent DNA polymerase.

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With technical assistance by R.Beyer

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Müller, W.E.G., Falke, D., Heicke, B. et al. Biological activity of 2-phenylethanol and its derivatives. Archiv f Virusforschung 40, 205–214 (1973). https://doi.org/10.1007/BF01242539

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  • DOI: https://doi.org/10.1007/BF01242539

Keywords

  • Infectious Disease
  • Biological Activity
  • Inhibitory Concentration
  • Kidney Cell
  • Uninfected Cell