Summary
A microbial agent, probably viral in nature, was recovered from the throat and faeces of patients with non-diphtheritic croup and from Day-Nursery-children. The agent is cytopathogenic in human embryo lung tissue cultures and after adaptation in monkey kidney cells, but not in common laboratory hosts or embryonated eggs. The agent haemagglutinates human erythrocytes. H-I tests were possible to perform. No complement-fixation was obtained with the agent as antigen. An antigenic analysis of 19 strains showed only one serological type to be prevalent. No relation was found to Polio, Echo, Adenoviruses, CA-virus, parotitic, or Sendai virus. No relationship was found to B or C group influenza virus, but FM-1 A` showed some relation in H-I tests, although not in neutralizing tests. Other evidence is presented, suggesting the relation with influenza virus A` to be improbable.
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The authors are indebted to Dr.K. Jensen (Sendai), Dr.R. M. Chanock (CA-virus), Dr.L. Heller (influenza antigens, antiserum and strains), Dr.A. Svedmyr (Adenovirus and Echo virus), and Dr.W. J. Mogabgab (Strain 2060) for making available sera and/or strains.
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Philipson, L., Wesslén, T. Recovery of a cytopathogenic agent from patients with non-diphtheritic croup and from Day-Nursery children. I. Properties of the agent. Archiv f Virusforschung 8, 77–94 (1958). https://doi.org/10.1007/BF01242314
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DOI: https://doi.org/10.1007/BF01242314